Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

286 Index
b-hydroxydecanoyl thioester dehydratase 196,
197
b-hydroxydecanoyl thioester isomerase 232
b-sheet 14–17
flavodoxin 18
superoxide dismutase 19
b-turn 14, 16
bifunctional catalysis 40
biosynthesis
acyl transfer reactions 99
alkaloids 222
biotechnology industry 5–6
importance of enzymes 3–7
biotin 170–71, 172
biotin synthase insertion reactions 249–50
bovine trypsin 85
Cahn–Ingold–Prelog rule 61, 272–3
camphor 179–80
camphor, stereospecific hydroxylation of 65,
145
Cannizzaro reaction 127, 128
carbanions and carbocations see under
carbon–carbon bond
carbohydrates 24–5, 109
carbon cycle 171
carbon–carbon bond formation 156–87
via carbanion equivalents 156, 158–79
via carbocation (carbonium ion)
intermediates 156, 179–83
via radical intermediates 183–7
carbonium ions see under carbon–carbon bond
carboxylases
biotin dependent 170–71, 172
Rubisco 171–3
vitamin K-dependent 173–5
carboxypeptidase A 46, 93, 94
carboxyphosphate 171
case studies
aspartate aminotransferase 215–18
chorismate mutase 233–6
EPSP synthase 204–6
fructose-1,6-bisphosphate aldolase 158–63
glutathione and trypanothione
reductases 137–41
HIV-1 protease 96–8
catalysis, enzymatic 2
acid/base 37–41
active site group determination 75–9
bifunctional 40
demonstration of 275
efficiencies 47, 56
nucleophilic 41–5
and protein dynamics 47
radicals in 240–52
strain energy 45, 111
thermodynamic model 31
catalysis, non-enzymatic biological 255–70
catalytic antibodies 259–65
catalytic polymers 269
catalytic RNA 255–9
synthetic enzyme models 265–9
catalytic efficiency 46, 56
catechol dioxygenases 148, 150, 151
chalcone synthase 188
chelating agents 92
chemical competence 71
chiral methyl groups 65–7, 113
chiral molecules 8
chiral products 61–2
nomenclature 61, 272–3
and stereochemical course of reaction 60–67
chloromethyl ketone inhibitors 86
chloroperoxidases 145
chorismate mutase 233–6
chorismate synthase 203
chorismic acid 203, 208
chymotrypsin 84–6, 88, 89, 116
citrate synthase 165
citric acid cycle 196, 198
Claisen enzymes 164–70
Claisen ester condensation 164, 166
codons 11–12
coenzyme A (CoA)
in acyl transfer 99–101
see also acetyl CoA
coenzymes 3–4
cofactors 20, 250–51
collagen 148
coniferyl alcohol 186
convergent evolution 88–9
copper ions 147, 184–5
covalent modification 75, 76
crown ethers 266, 267
cyclisation reactions 264–5
cyclodextrins 266–9
cyclohexanone mono-oxygenase 136, 137
cyclosporin A 5
cysteine proteases 89–92, 117
cysteinyl radical 244–5