Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

Index
acetoacetate decarboxylase 38–9, 42, 43
acetyl CoA carboxylase 170
acetyl coenzyme A (CoA) 65, 100–101, 109
Claisen enzymes 164–5
fatty acid and polyketide biosynthesis 166–70
acetylcholinesterase 47, 116
acid/base catalysis 37–41
aconitase 197–9, 198
activation energy 31, 36
active site 32, 75–81
aconitase 198
alcohol dehydrogenase 127
aspartame aminotransferase 217
bovine trypsin 85
carboxypeptidase A 93
defined 19
determination of catalytic groups 75–9
ketosteroid isomerse 40
thermolysin 93
acyl coenzyme A (CoA) dehydrogenase 131–4
acyl phosphate intermediate 69–70
acyl transfer reactions 99–101
addition and elimination reactions 193–206
ammonia lyases 199–202
EPSP synthase 204–6
hydratases and dehydratases 194–9
phosphate and pyrophospate 202–4
adenosine 5 0 -diphosphate (ADP) 108
adenosine 5 0 -triphosphate (ATP) 70, 102, 170–71
as coenzyme 106–9
phosphoryl transfer 106, 108–9
affinity labelling 75–6
AIDS 96
alanine 8
alanine racemase 213
alcohol dehydrogenase 62–3, 63, 73, 127
stereospecificity 125–6
alcohols, phosphorylation 108
aldol reactions 158
aldolases 158–63
in organic synthesis 160, 163
aldose–ketose isomerases 231
alkaline phosphotase 104, 105
alkaloid biosynthesis 222–4
allylic isomerases 231–3
a-amino acids see amino acids
a-chymotrypsin 84–6, 88, 89
a-helix 14, 15, 17
a-ketoglutarate-dependent dioxygenases 147–8,
185
( )-a-pinene synthase 181, 182
a=b-structures 17, 44
amine oxidases 251
amino acid decarboxylases 213–14, 215
amino acids
abbreviations 274
active site modification 75, 76
a-, general structure of 8
aromatic 193
b- and g-position reactions 218–21
N-pyruvoyl-dependent decarboxylases 222
oxidised cofactors 250–52
pyridoxal 5 0 -phosphate-dependent
reactions 210, 211–15
sequences in polypeptides 10–13
side chains 8–10
transformation reactions 210–24
ammonia lyases 199–202
anaerobic ribonucleotide reductase 249
antibodies, catalytic 259–65, 260
anti-parallel b-structures 17, 19
aromatic amino acids 193
aromatic dihydroxylating dioxygenases 148–49
ascorbic acid 3, 147–8
aspartate aminotransferase 215–18,
224
aspartate racemase 227–8
aspartyl proteases 95–8
assay of enzymes 51–3
asymmetric induction 61
ATP see adenosine triphosphate
AZT 6
bacteriorhodopsin 25
benzylsuccinate synthase 252
b-chloro-d-alanine 213–14
b-hydroxycarboxylic acids, dehydration of
196–9
285