Introduction to Enzyme and Coenzyme Chemistry - E-Library Home

Enzymatic Addition/Elimination Reactions 209
Ammonia lyases
N.P. Botting, A.A. Jackson & D. Gani (1989) 15 N-isotope and double isotope fractionation
studies of the mechanism of 3-methylaspartase: concerted elimination of ammonia
from (2S,3S)-3-methylaspartic acid. J. Chem. Soc. Chem. Commun., 1583–5.
L. Poppe (2001) Methylidene-imidazolone: a novel electrophile for substrate activation.
Curr. Opin. Chem. Biol., 5, 512–24.
T.F. Schwede, J. Retey & G.E. Schulz (1999) Crystal structure of histidine ammonia
lyase revealing a novel polypeptide modiWcation as the catalytic electrophile.
Biochemistry, 38, 5355–61.
Elimination of phosphates
K.S. Anderson & K.A. Johnson (1990) Kinetic and structural analysis of enzyme
intermediates: lessons from EPSP synthase. Chem. Rev., 90, 1131–49.
S. Dhe-Paganon, J. Magrath & R.H. Abeles (1994) Mechanism of mevalonate
pyrophosphate decarboxylase: evidence for a carbocationic transition state.
Biochemistry, 33, 13355–62.
M.N. Ramjee, S. Balasubramanian, C. Abell, J.R. Coggins, G.M. Davies, T.R. Hawkes,
D.J. Lowe & R.N.F. Thorneley (1992) Reaction of (6R)-6-F-EPSP with recombinant
E. coli chorismate synthase generates a stable Xavin mononucleotide semiquinone
radical. J. Am. Chem. Soc., 114, 3151–3.
M.N. Ramjee, J.R. Coggins, T.R. Hawkes, D.J. Lowe & R.N.F. Thorneley (1991)
Spectrophotometric detection of a modiWed Xavin mononucleotide (FMN) intermediate
formed during the catalytic cycle of chorismate synthase. J. Am. Chem. Soc., 113,
8566–7.
W.C. Stallings, S.S. Abdel-Meguid, L.W. Lim, H.S. Shieh, H.E. Dayringer,
N.K. Leimgruber, R.A. Stegeman, K.S. Anderson, J.A. Sikorski, S.R. Padgette
& G.M. Kishore (1991) Structure and topological symmetry of the glyphosate target
5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold. Proc. Natl.
Acad. Sci., USA, 88, 5046–50.
D.R. Welch, K.W. Cole & F.H. Gaertner (1994) Chorismate synthase of Neurospora
crassa: aXavoprotein. Arch. Biochem. Biophys., 165, 505–18.