WHO monographs on selected medicinal plants - travolekar.ru

<strong>WHO</strong> <strong>monographs</strong> on selected medicinal plants
acetyl-boswellic acids (20.0 mg/kg bw) significantly reduced the clinical
symptoms in guinea-pigs with experimental autoimmune encephalomyelitis
between days 11 and 21. However, the inflammatory infiltrates in
the brain and the spinal cord were not significantly less extensive in the
treated animals than in the respective control group. The multiple intraperitoneal
administrations of boswellic acids did not inhibit the ionophorechallenged
ex vivo release of leukotrienes B4 and C4 from polymorphonuclear
leukocytes separated from the blood of guinea-pigs with
experimental autoimmune encephalomyelitis or the biosynthesis of leukotrienes
in vitro (40). Suspensions of rat peritoneal polymorphonuclear
leukocytes elicited with glycogen, stimulated by calcium and ionophore
to produce leukotrienes and 5-15-hydroxyeicosateraenoic acid (HETE)
from endogenous arachidonic acid, were treated with various concentrations
of an ethanol extract of the crude drug. A concentration-dependent
inhibition of leukotriene B4 and 5-HETE production was observed. All
products of 5-lipoxygenase from endogenous arachidonic acid in polymorphonuclear
leukocytes were reduced (41).
Miscellaneous activities
Intragastric administration of a 50% ethanol extract of the crude drug,
at a dose of 250.0 mg/kg bw, to rats reduced blood glucose levels (42).
Intravenous administration to dogs of a 50% ethanol extract, at a dose
of 50.0 mg/kg bw, reduced blood pressure (42). Intragastric administration
of the crude drug at a dose of 100.0 mg/kg bw to cockerels,
rabbits and rats fed a high cholesterol diet reduced serum cholesterol
by 25–45% (26). Intragastric administration of the crude drug, at a dose
of 100.0–500.0 mg/kg bw did not reduce fever in rats, rabbits or dogs
(26). Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal
medicine from Boswellia serrata resin, attenuated experimental ileitis
in animals (43).
Toxicology
The gestation period or parturition time in pregnant rats and the onset
time of castor oil-induced diarrhoea were unaffected by the extract and
no significant effect was seen on cardiovascular, respiratory and central
nervous system functions. Intragastric administration of the crude drug
to dogs, rabbits or rats, at a dose of 500.0 or 1000.0 mg/kg bw, did not
have ulcerogenic effects. The oral and intraperitoneal median lethal doses
were greater than 2.0 g/kg bw in mice and rats (28). Intragastric administration
of the crude drug to monkeys (500.0 mg/kg bw), mice (2.0 g/kg
bw) or rats (1.0 g/kg bw) for 6 months produced no observable behavioural,
biochemical or histological abnormalities (44).
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