WHO monographs on selected medicinal plants - travolekar.ru

Gummi Boswellii
H 3 C CH 3
H
CH 3 CH 3
CH 3
R
O
H H CH 3
H
H 3 C CO 2 H
H CH 3
H
H 3 C
X
CH 3 CH 3
H CH 3
R
O
H H CH 3
H
H 3 C CO 2 H
-Boswellic acid
R = H
3-O-Acetyl--boswellic acid
R = CO-CH 3
-Boswellic acid
R = H X = H 2
3-O-Acetyl--boswellic acid
R = CO-CH 3 X = H 2
11-Oxo--boswellic acid
R = H X = O
3-O-Acetyl-11-oxo--boswellic acid
R = CO-CH 3 X = O
Uses described in traditional medicine
Treatment of abdominal pain, asthma, coughs, dysentery, fever, jaundice,
kidney stones, pimples, sores and stomach disorders (5). Also used as an
antivenin and an emmenagogue (24, 25).
Pharmacology
Experimental pharmacology
Analgesic activity
Intragastric administration of the gum at doses ranging from 100.0–
500.0 mg/kg body weight (bw) had no analgesic effects in dogs, rabbits or
rats (26–28). However, administration of a non-phenolic fraction of the
crude drug produced analgesia in 60% of rats treated with a dose of
60.0 mg/kg bw. A dose of 150.0 mg/kg bw induced analgesia in 70% of
rats (29). The degree of analgesia was comparable to a dose of 3–4.5 mg/
kg bw of morphine. A dose of 150.0 mg/kg bw also caused a 70% reduction
in spontaneous motor activity that lasted for 2 hours (29).
Anticomplementary activity
Boswellic acids exhibited anticomplementary activity in vitro, as assessed
by the reduction of immune-induced haemolysis of antibody-coated
sheep erythrocytes by pooled guinea-pig serum (30). The decrease in immune-induced
haemolysis was due to inhibition of C3-convertase of the
classical complement pathway. The threshold concentration for inhibiting
C3-convertase was found to be 100.0 μg/ml (30).
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