WHO monographs on selected medicinal plants - travolekar.ru

Cortex Berberidis
Radioactive residues
Where applicable, consult the <strong>WHO</strong> guidelines on assessing quality of
herbal medicines with reference to contaminants and residues (7).
Chemical assays
To be established according to national requirements. Since the major
constituents are berberine and related alkaloids, the high-performance
liquid chromatography method of analysis established for berberine in
Rhizoma Hydrastis (10) may be employed for standardization.
Major chemical constituents
The major constituents are isoquinoline alkaloids, principally berberine,
occurring at a concentration up to 4.5%. Other major alkaloids include
oxyacanthine (0.04%), berbamine (0.6–1.2%), columbamine (0.3%), jatrorrhizine
(0.4%) and magnoflorine (2.1%) (11–13). Structures of berbamine,
berberine, columbamine, jatrorrhizine and magnoflorine are presented
below.
Berbamine
Berberine
O
O
OCH 3
OCH 3
H 3 CO
H 3 CO
N +
N
H
O
H
N
CH 3
OCH 3
Columbamine
OH
OCH 3
CH 3
OH
O
H 3 CO
OCH 3
N +
Jatrorrhizine
OCH 3
OH
H 3 CO
H 3 CO
OCH 3
N +
HO
HO
H 3 CO
H
N + CH 3
CH 3
Magnoflorine
Medicinal uses
Uses supported by clinical data
None.
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