WHO monographs on selected medicinal plants - travolekar.ru

Cortex Viburni Prunifolii
Warnings
Use of the crude drug during pregnancy should only take place under the
supervision of a health care professional.
Precautions
Carcinogenesis, mutagenesis, impairment of fertility
A 30% ethanol extract of the bark was not mutagenic in the Ames test at
concentrations of 200 μl/disc in Salmonella typhimurium strains TA98
and TA100. Metabolic activation had no effect on the results (23).
Nursing mothers
No safety data are available, thus the use of the crude drug during breastfeeding
is not recommended.
Paediatric use
No safety data are available, thus the use of the crude drug for children
under the age of 12 years is not recommended.
Other precautions
No information was found.
Dosage forms
Crude drug, aqueous and ethanol extracts, fluidextracts and tinctures. Storage:
protect from air, light, moisture, excessive heat and insect infestation (3).
Posology
(Unless otherwise indicated)
Powdered bark: 2.5–5 g as an infusion or decoction three times daily. Liquid
extract (1:1) in 70% ethanol: dose 4–8 ml three times daily. Tincture
(1:5 in 70% ethanol): 5–10 ml three times daily (1, 3).
References
1. British herbal pharmacopoeia. Exeter, British Herbal Medicine Association,
1996.
2. Farmacopea homeopática de los estados unidos mexicanos [Homeopathic
Pharmacopoeia of the United States of Mexico]. Mexico City, Secretaría de
Salud, Comisión Permanente de la Farmacopea de los Estados Unidos Mexicanos,
1998 [in Spanish].
3. Upton R et al., eds. Black haw bark. Viburnum prunifolium. In: American
herbal pharmacopeia. Santa Cruz, CA, American Herbal Pharmacopeia,
2000.
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