WHO monographs on selected medicinal plants - travolekar.ru

<strong>WHO</strong> <strong>monographs</strong> on selected medicinal plants
Pharmacopeia) was investigated. Addition of 0.1 ml of an ethanol extract
of the bark to a 100-ml bath chamber containing isolated guinea-pig uterine
strips, reduced normal and resting tone, and decreased the rate and
amplitude of spontaneous contractions (15). The antispasmodic effects
were observed 5–15 minutes after addition and when the extract was removed
the contractions resumed. A synergistic effect was observed in rat
uteri treated with the fluidextract of the bark and 1 mg papaverine hydrochloride
(16). In a similar test, the essential oil of the bark reduced uterine
contractions in isolated rat uteri (concentration not stated) (17).
An aqueous, 95% ethanol, methanol or fluidextract of the bark reduced
spontaneous uterine contractions in the isolated uterus from female
rats, at a concentration of 1:200, or 1mM (11, 18, 19). Methanol extracts
of the bark had antispasmodic effects in estrone-primed barium
chloride-stimulated rat uterine horns in vitro (11). Scopoletin, isolated
from the bark had antispasmodic properties in vitro in estrone-primed
and barium chloride-induced rat uteri. The concentration needed to produce
a 50% decrease in the contraction amplitude of a single uterine horn
was 0.09 mg/ml. Similar effects were observed in rodents in a study of
oxytocin- and ergonovine-induced uterine contractions (20). A fluidextract
of the bark (concentration not stated) reduced spontaneous contractions
in rat uteri in vitro. Addition of a 95% ethanol extract (concentration
not stated) of the bark to the bath medium prevented barium chloride
and acetylcholine-induced spasms in isolated guinea-pig ileum (21).
A methanol extract (100 g dried bark), as well as the ethyl acetate and
butanol fractions of the bark, inhibited spontaneous contractions of isolated
rat uteri by 50% at concentrations of 2.0–200.0 μg/ml. A decrease in
the tone and amplitude of acetylcholine-induced contractions was also
observed. The median inhibitory concentration was 60 μg/ml for the
crude extract, 36.0 μg/ml for the ethyl acetate fraction and 50 μg/ml for
the butanol fraction. 2´-p-Coumaroyldihydropenstemide was the active
constituent (22).
Clinical pharmacology
No controlled clinical trials were found.
Adverse reactions
No information was found.
Contraindications
Cortex Viburni Prunifolii is contraindicated in cases of hypersensitivity
or allergy to the crude drug.
370