WHO monographs on selected medicinal plants - travolekar.ru

Cortex Viburni Prunifolii
OH
O
CH 3
HO
O
O
OH
OH
HO
H
HO
HO
H
H
H
O
H
O
CH 3
HO
O
HO
O
O
OH
O
O
HO
OH O
Amentoflavone
HO
Esculetin
OH
Patrinoside
Uses described in pharmacopoeias and well established documents
Orally for the treatment of dysmenorrhoea and asthma (1, 10, 11).
Uses described in traditional medicine
Used to treat menstrual irregularities and nervous tension. Also used as
an antispasmodic, diuretic and tonic (5).
Pharmacology
Experimental pharmacology
Antispasmodic activity
The data describing the antispasmodic effects of the crude drug are conflicting.
Up until 1940, the plant material used was not properly identified
and was thought to be commonly adulterated with other Viburnum species
or even the inert mountain maple bark (Acer spicatum) (12). Thus, the
lack of activity observed prior to 1940 may have been due to the use of
adulterated plant materials.
Oral administration of a hot aqueous extract of the bark to pregnant
dogs (50.0 ml/animal) or pregnant rabbits (25 ml/animal) had no inhibitory
or stimulatory effects on uterine contractions (13). Intravenous administration
of a 70% ethanol extract to cats at a dose of 8 ml/animal did
not relax spontaneous uterine spasms (13). In addition, a fluidextract and
hot aqueous extract were not active in vitro in tests in rat uteri, when assayed
at a concentration of 1:1000 or 2:1000 (14).
Scientific research performed after 1940 with properly identified plant
materials has yielded more positive results. In 1941, a modified version of
the oxytocic assay from the 11th edition of the United States Pharmacopeia,
in which the crude drug was tested for its ability to neutralize the
oxytocic activity of the solution of posterior pituitary (United States
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