WHO monographs on selected medicinal plants - travolekar.ru

WHO monographs on selected medicinal plants - travolekar.ru WHO monographs on selected medicinal plants - travolekar.ru

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ong>WHOong> ong>monographsong> on selected medicinal plants Adverse reactions No information was found. Contraindications Allergy to the plant material. Warnings No information was found. Precautions General No information was found. Drug interactions No information was found. Drug and laboratory test interactions No information was found. Carcinogenesis, mutagenesis, impairment of fertility An aqueous extract of the crude drug was not mutagenic in the Ames test at a concentration of 40.0–50.0 mg/plate in Salmonella typhimurium strains TA98 and TA100 (44, 45). The extract was also not mutagenic when administered by intraperitoneal injection to mice at a dose of 4.0 mg/ kg bw, equal to 10–40 times the amount used in humans (44). An infusion of the crude drug inhibited aflatoxin B1-induced mutagenesis in Salmonella typhimurium strains TA98 and TA100 at a concentration of 40.0 mg/ plate (46). Metabolic activation was required for activity. Pregnancy: teratogenic effects No information was found. Pregnancy: non-teratogenic effects Use of the crude drug during pregnancy requires the supervision of a health care professional. Nursing mothers No safety data are available, thus the use of the crude drug by breastfeeding mothers is not recommended. Paediatric use No safety data are available, thus the use of the crude drug in children under the age of 12 years is not recommended. 360

Ramulus cum Uncis Uncariae Other precautions No information was found. Dosage forms Crude drug (1). Store in a dry place (1). Posology (Unless otherwise indicated) Oral daily dose: 3–12 g of the crude drug, added to a decoction, taken in divided doses (1). References 1. Pharmacopoeia of the People’s Republic of China. Vol. I (English ed.). Beijing, Chemical Industry Press, 2005. 2. The Japanese pharmacopoeia, 14th ed., Suppl. 1 (English ed.). Tokyo, Ministry of Health, Labour and Welfare, 2004. 3. The Korean herbal pharmacopoeia (English ed.). Seoul, Korea Food and Drug Administration, 2002. 4. Hänsel R et al., eds. Hagers Handbuch der pharmazeutischen Praxis. Vol. 6, 5th ed. Springer, Berlin. 5. Farnsworth NR, ed. NAPRALERT database. University of Illinois at Chicago, IL (an online database available directly through the University of Illinois at Chicago or through the Scientific and Technical Network [STN) of Chemical Abstracts Services) 30 June 2005. 6. Medicinal plants in China. Manila, Philippines, World Health Organization Regional Office for the Western Pacific, 1989 (ong>WHOong> Regional Publications Western Pacific, Series No. 2). 7. Perry LM, Metzger J. Medicinal plants of east and southeast Asia: attributed properties and uses. Cambridge, MA, MIT Press, 1980. 8. Ridsdale CE. A revision of Mitragyna and Uncaria (Rubiaceae). Blumea, 1978, 24:43–100. 9. Kariyone T, Koiso R. Atlas of medicinal plants. Osaka, Nihon Rinshosha, 1973. 10. Laus G, Keplinger D. Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance liquid chromatography. Journal of Chromatography A, 1994, 662:243–249. 11. Laus G, Keplinger D. Radix Uncariae tomentosae (Willd.) DC – Eine monographische Beschreibung. Zeitschrift für Phytotherapie, 1997, 18:122–126. 12. Stuppner H, Sturm S, Konwalinka G. HPLC analysis of the main oxindole alkaloids from Uncaria tomentosa. Chromatographia, 1992, 34:597–560. 13. Sakakibara I et al. Chemical and pharmacological evaluations of Chinese crude drug “Gou-teng”. Natural Medicines, 1998, 52:353–359. 361

Ramulus cum Uncis Uncariae<br />

Other precauti<strong>on</strong>s<br />

No informati<strong>on</strong> was found.<br />

Dosage forms<br />

C<strong>ru</strong>de d<strong>ru</strong>g (1). Store in a dry place (1).<br />

Posology<br />

(Unless otherwise indicated)<br />

Oral daily dose: 3–12 g of the c<strong>ru</strong>de d<strong>ru</strong>g, added to a decocti<strong>on</strong>, taken in<br />

divided doses (1).<br />

References<br />

1. Pharmacopoeia of the People’s Republic of China. Vol. I (English ed.). Beijing,<br />

Chemical Industry Press, 2005.<br />

2. The Japanese pharmacopoeia, 14th ed., Suppl. 1 (English ed.). Tokyo, Ministry<br />

of Health, Labour and Welfare, 2004.<br />

3. The Korean herbal pharmacopoeia (English ed.). Seoul, Korea Food and<br />

D<strong>ru</strong>g Administrati<strong>on</strong>, 2002.<br />

4. Hänsel R et al., eds. Hagers Handbuch der pharmazeutischen Praxis. Vol. 6,<br />

5th ed. Springer, Berlin.<br />

5. Farnsworth NR, ed. NAPRALERT database. University of Illinois at Chicago,<br />

IL (an <strong>on</strong>line database available directly through the University of Illinois<br />

at Chicago or through the Scientific and Technical Network [STN) of<br />

Chemical Abstracts Services) 30 June 2005.<br />

6. Medicinal <strong>plants</strong> in China. Manila, Philippines, World Health Organizati<strong>on</strong><br />

Regi<strong>on</strong>al Office for the Western Pacific, 1989 (<str<strong>on</strong>g>WHO</str<strong>on</strong>g> Regi<strong>on</strong>al Publicati<strong>on</strong>s<br />

Western Pacific, Series No. 2).<br />

7. Perry LM, Metzger J. Medicinal <strong>plants</strong> of east and southeast Asia: attributed<br />

properties and uses. Cambridge, MA, MIT Press, 1980.<br />

8. Ridsdale CE. A revisi<strong>on</strong> of Mitragyna and Uncaria (Rubiaceae). Blumea,<br />

1978, 24:43–100.<br />

9. Kariy<strong>on</strong>e T, Koiso R. Atlas of <strong>medicinal</strong> <strong>plants</strong>. Osaka, Nih<strong>on</strong> Rinshosha,<br />

1973.<br />

10. Laus G, Keplinger D. Separati<strong>on</strong> of stereoisomeric oxindole alkaloids from<br />

Uncaria tomentosa by high performance liquid chromatography. Journal of<br />

Chromatography A, 1994, 662:243–249.<br />

11. Laus G, Keplinger D. Radix Uncariae tomentosae (Willd.) DC – Eine m<strong>on</strong>ographische<br />

Beschreibung. Zeitschrift für Phytotherapie, 1997, 18:122–126.<br />

12. Stuppner H, Sturm S, K<strong>on</strong>walinka G. HPLC analysis of the main oxindole<br />

alkaloids from Uncaria tomentosa. Chromatographia, 1992, 34:597–560.<br />

13. Sakakibara I et al. Chemical and pharmacological evaluati<strong>on</strong>s of Chinese<br />

c<strong>ru</strong>de d<strong>ru</strong>g “Gou-teng”. Natural Medicines, 1998, 52:353–359.<br />

361

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