WHO monographs on selected medicinal plants - travolekar.ru

WHO monographs on selected medicinal plants - travolekar.ru WHO monographs on selected medicinal plants - travolekar.ru

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ong>WHOong> ong>monographsong> on selected medicinal plants 46. Han D, Tachibana H, Yamada K. Inhibition of environmental estrogen-induced proliferation of human breast carcinoma MCF-7 cells by flavonoids. In Vitro Cell Development and Biology, 2001, 37:275–282. 47. Tanos V et al. Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro. European Journal of Obstetrics and Gynecology Reproduction Biology, 2002, 37:188–194. 48. Ju YH et al. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Research, 2002, 62:2474–2477. 49. Constantinou A et al. Consumption of soy products may enhance the breast cancer preventive effects of tamoxifen. Proceedings of the American Association of Cancer Research, 2001, 42:826. 50. Gotoh T et al. Chemoprevention of N-nitroso-N-methylurea-induced rat mammary cancer by miso and tamoxifen, alone and in combination. Japanese Journal of Cancer Research, 1998, 89:487–495. 352

Ramulus cum Uncis Uncariae Definition Ramulus cum Uncis Uncariae consists of the dried hook-bearing stem branch of Uncaria rhynchophylla (Miq.) Jacks, U. macrophylla Wall., U. hirsuta Havil., U. sinensis (Oliv.) Havil. or U. sessilifructus Roxb. (Rubiaceae) (1–3). Synonyms Uncaria rhynchophylla (Miq.) Jacks, Nauclea rhynchophylla Miq., Ourouparia rhynchophylla Matsum (4). Selected vernacular names Choto-ko, chotoko, cho-to-kou, gout eng, kagikazura (1, 4, 5). Geographical distribution Indigenous to China and Japan (6, 7). Description A deciduous twining shrub up to 10 m long. Branches brownish, glabrous, occasionally bearing compressed, hooked thorns. Young stems slender, square to slightly angular, glabrous. Stipules of the plagiotropic shoot 6–10 mm long, those of the orthotropic shoot considerably larger, up to 30 mm long, inside glabrous with glandular hairs at the base, outside glabrous, margins entire, narrowly triangular, deeply bifid for over two thirds of the length, lobes narrowly triangular to triangular-lanceolate. Leaves opposite, ovate to ovate-oblong or elliptic to elliptic-oblong, 5–12 × 3–7 cm, membranous, glabrous on either side; apex acute to cuspidate; base cuneate to truncate; lateral nerves 4–8 pairs, axils with sparsely hairy domatia, tertiary nerves curved, impressed, ultimate venation reticulate. Inflorescence an axillary or terminal peduncled solitary head. Flowers yellow, subsessile on the receptacle. Hypanthium 1–2 mm, densely hairy. Calyx 1 mm, pubescent; lobes oblong to slightly triangular, 0.5–1 mm, sparsely pubescent. Corolla tube 6–8 (6–10 mm), outside 353

Ramulus cum Uncis Uncariae<br />

Definiti<strong>on</strong><br />

Ramulus cum Uncis Uncariae c<strong>on</strong>sists of the dried hook-bearing stem<br />

branch of Uncaria rhynchophylla (Miq.) Jacks, U. macrophylla Wall.,<br />

U. hirsuta Havil., U. sinensis (Oliv.) Havil. or U. sessilif<strong>ru</strong>ctus Roxb.<br />

(Rubiaceae) (1–3).<br />

Syn<strong>on</strong>yms<br />

Uncaria rhynchophylla (Miq.) Jacks, Nauclea rhynchophylla Miq., Ourouparia<br />

rhynchophylla Matsum (4).<br />

Selected vernacular names<br />

Choto-ko, chotoko, cho-to-kou, gout eng, kagikazura (1, 4, 5).<br />

Geographical distributi<strong>on</strong><br />

Indigenous to China and Japan (6, 7).<br />

Descripti<strong>on</strong><br />

A deciduous twining sh<strong>ru</strong>b up to 10 m l<strong>on</strong>g. Branches brownish, glabrous,<br />

occasi<strong>on</strong>ally bearing compressed, hooked thorns. Young stems<br />

slender, square to slightly angular, glabrous. Stipules of the plagiotropic<br />

shoot 6–10 mm l<strong>on</strong>g, those of the orthotropic shoot c<strong>on</strong>siderably larger,<br />

up to 30 mm l<strong>on</strong>g, inside glabrous with glandular hairs at the base, outside<br />

glabrous, margins entire, narrowly triangular, deeply bifid for over two<br />

thirds of the length, lobes narrowly triangular to triangular-lanceolate.<br />

Leaves opposite, ovate to ovate-obl<strong>on</strong>g or elliptic to elliptic-obl<strong>on</strong>g,<br />

5–12 × 3–7 cm, membranous, glabrous <strong>on</strong> either side; apex acute to cuspidate;<br />

base cuneate to t<strong>ru</strong>ncate; lateral nerves 4–8 pairs, axils with sparsely<br />

hairy domatia, tertiary nerves curved, impressed, ultimate venati<strong>on</strong><br />

reticulate. Inflorescence an axillary or terminal peduncled solitary head.<br />

Flowers yellow, subsessile <strong>on</strong> the receptacle. Hypanthium 1–2 mm,<br />

densely hairy. Calyx 1 mm, pubescent; lobes obl<strong>on</strong>g to slightly triangular,<br />

0.5–1 mm, sparsely pubescent. Corolla tube 6–8 (6–10 mm), outside<br />

353

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