WHO monographs on selected medicinal plants - travolekar.ru

Fructus Tribuli
Medicinal uses
Uses supported by clinical data
None.
Uses described in pharmacopoeias and well established documents
Orally for the treatment of cough, headache and mastitis (1).
Although clinical trials have assessed the use of the crude drug for
the symptomatic treatment of angina pectoris and male infertility
(16–22), randomized controlled clinical trials are needed before the
use of the crude drug can be recommended for the treatment of these
conditions.
Uses described in traditional medicine
Orally for the treatment of abdominal distension, diarrhoea, kidney
stones, nosebleeds and vitiligo (5, 23). Also used as an aphrodisiac, diuretic,
galactagogue, general tonic and uterine tonic (5).
Pharmacology
Experimental pharmacology
Angiotensin-converting enzyme inhibitory effects
The renin-angiotensin-aldosterone system, including angiotensinconverting
enzyme plays an important role in the control of blood pressure
and fluid volume (24, 25). An aqueous extract of the fruit (1 g fruit in
10 ml water) inhibited the activity of angiotensin-converting enzyme in
vitro at a concentration of 0.33 mg/ml (24). The mechanism of action of
the aqueous extract (500 mg fruit in water 2:1 w/v) was investigated in
2K1C hypertensive rats by measurement of circulatory and local angiotensin
converting enzyme activity in aorta, heart, kidney and lung. Hypertension
was induced using a silver clip on the renal artery inserted by
surgery. The animals were treated with a single oral daily dose of 10 mg/
kg body weight (bw) of a lyophilized aqueous extract of the fruit for
4 weeks. The systolic blood pressure was increased in 2K1C rats as compared
with control rats. The systolic blood pressure of rats treated with
the crude drug extract was significantly decreased compared to hypertensive
rats (p < 0.05). The angiotensin-converting enzyme activity in all tissues
of 2K1C rats including aorta, heart, kidney and lung as well as in the
serum was significantly increased compared to that of normal rats. The
angiotensin-converting enzyme activity in all tissues of hypertensive rats
treated with the fruit extract was significantly lower than that of control
hypertensive rats (26).
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