WHO monographs on selected medicinal plants - travolekar.ru

Cortex Salicis
Warnings
In children under the age of 12 years, Cortex Salicis should only be used
on the advice of a health care professional due to the possibility of Reye’s
syndrome. In cases of a child or adolescent who has become very ill with
severe vomiting, drowsiness or loss of consciousness following a viral infection,
Reye’s syndrome should be suspected. This extremely rare, lifethreatening
disease requires immediate medical attention.
In cases of severe liver or renal dysfunction, coagulation disorders,
gastric/duodenal ulcer and glucose-6-phosphate dehydrogenase deficiency,
the product should only be taken under medical supervision.
Consult a health care professional in cases of fever (> 39 C), lasting
longer than 3 days. A health care professional should also be consulted if
acute conditions of swelling of joints, redness and impaired mobility persist
or worsen during the first week of use of Cortex Salicis.
Precautions
General
The use of Cortex Salicis in patients with hypersensitivity to other nonsteroidal
anti-inflammatory drugs is not recommended. Use should be
avoided in people with asthma because severe reactions (acute bronchospasms)
could be induced (16).
Drug interactions
Currently there are no data indicating that the crude drug interacts with
anticoagulant drugs such as coumarin and heparin. However, Cortex Salicis
may increase the effects of anticoagulants. Patients on anticoagulant
therapy should not use products containing the crude drug without the
supervision of a health care professional (7).
Carcinogenesis, mutagenesis, impairment of fertility
Oral administration of a 40% ethanol extract of the bark did not disrupt
the estrous cycle, or inhibit ovulation or fertility when administered to
female rats and rabbits at a dose of 1.6 ml/kg bw (26).
Pregnancy: teratogenic effects
Oral administration of a 40% ethanol extract of the bark to female rats
and rabbits at a dose of 1.6 ml/kg bw during pregnancy was not teratogenic
(26).
Pregnancy: non-teratogenic effects
See Contraindications.
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