WHO monographs on selected medicinal plants - travolekar.ru
WHO monographs on selected medicinal plants - travolekar.ru
WHO monographs on selected medicinal plants - travolekar.ru
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<str<strong>on</strong>g>WHO</str<strong>on</strong>g> <str<strong>on</strong>g>m<strong>on</strong>ographs</str<strong>on</strong>g> <strong>on</strong> <strong>selected</strong> <strong>medicinal</strong> <strong>plants</strong><br />
Adverse reacti<strong>on</strong>s<br />
Adverse reacti<strong>on</strong>s have been reported in some clinical trials. A review of<br />
30 studies involving 11 506 subjects reported a total of 246 adverse events,<br />
thus representing an adverse reacti<strong>on</strong> rate of approximately 2% (4). The<br />
major reacti<strong>on</strong>s reported included acne, changes to the menst<strong>ru</strong>al cycle,<br />
dizziness, gastrointestinal distress, increased menst<strong>ru</strong>al flow, nausea, skin<br />
reacti<strong>on</strong>s, urticaria and weight gain (4). Minor adverse events include fatigue,<br />
hair loss, increased intraocular pressure, palpitati<strong>on</strong>s, polyurea,<br />
sweating and vaginitis (4, 57).<br />
C<strong>on</strong>traindicati<strong>on</strong>s<br />
F<strong>ru</strong>ctus Agni Casti should not be used during pregnancy (35).<br />
Warnings<br />
No informati<strong>on</strong> available.<br />
Precauti<strong>on</strong>s<br />
General<br />
Patients reporting a feeling of tensi<strong>on</strong> and swelling of the breasts or menst<strong>ru</strong>al<br />
disturbances should c<strong>on</strong>sult a health care provider for a medical<br />
diagnosis (66).<br />
D<strong>ru</strong>g interacti<strong>on</strong>s<br />
Although no interacti<strong>on</strong>s have been documented, the reported dopaminergic<br />
effect may reduce the efficacy of dopamine-receptor antag<strong>on</strong>ists (3).<br />
Furthermore, due to its potential horm<strong>on</strong>al effects, F<strong>ru</strong>ctus Agni Casti<br />
may interfere with the effectiveness of oral c<strong>on</strong>traceptives and horm<strong>on</strong>e<br />
replacement therapy (67).<br />
Carcinogenesis, mutagenesis, impairment of fertility<br />
Intragastric administrati<strong>on</strong> of an ethanol f<strong>ru</strong>it extract to male and female<br />
rats at doses up to 80 times the recommended human daily dose had no<br />
effect <strong>on</strong> fertility, mating behaviour, pregnancy or lactati<strong>on</strong> (3). No pathological<br />
changes were observed in any of the offspring of treated animals<br />
when compared with those animals treated with vehicle c<strong>on</strong>trol (3).<br />
Pregnancy: n<strong>on</strong>-teratogenic effects<br />
See C<strong>on</strong>traindicati<strong>on</strong>s.<br />
Pregnancy: teratogenic effects<br />
Intragastric administrati<strong>on</strong> of an ethanol f<strong>ru</strong>it extract to rats and rabbits at<br />
doses up to 100 and 74 times higher than the human daily dose, respec-<br />
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