WHO monographs on selected medicinal plants - travolekar.ru

Rhizoma Picrorhizae
A preliminary clinical trial involving 36 patients with bronchial asthma
assessed the efficacy of an extract of the crude drug. Powdered crude drug
at a dose of 75 mg twice daily was administered for 2 weeks. The study
reported that 53% of patients had no attacks or chest symptoms, 25%
had occasional attacks, which were reduced in severity after treatment.
Treatment did not improve the condition of patients who smoked or regularly
drank alcohol, and was not effective for acute attacks (18).
In a randomized, double-blind placebo-controlled trial involving patients
diagnosed with acute viral hepatitis (hepatitis B surface antigennegative),
a powder of the crude drug was administered orally (375 mg
three times a day) for 2 weeks (n = 15) or a matching placebo was given
(n = 18). The difference in values of bilirubin, serum glutamic oxaloacetic
transaminase and serum glutamic pyruvic transaminase between the group
that received the placebo and the group that received the treatment with
the crude drug was significant. The time in days required for total serum
bilirubin to drop to an average value of 2.5 mg% was 75.9 days in patients
who received the placebo versus 27.4 days in the treatment group (19).
Adverse reactions
No information was found.
Contraindications
No information was found.
Warnings
No information was found.
Precautions
Carcinogenesis, mutagenesis, impairment of fertility
No information was found.
Pregnancy: teratogenic effects
Intragastric administration of a dried 70% methanol extract of the rhizome
was not teratogenic in pregnant rats when administered from day 13
of pregnancy onwards at doses of 250.0–500.0 mg/kg bw (41).
Pregnancy: non-teratogenic effects
Intragastric administration of a dried 70% methanol extract of the rhizome
did not induce abortion in pregnant rats when administered from
day 13 of pregnancy onwards at doses of 250–500.0 mg/kg bw (41).
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