WHO monographs on selected medicinal plants - travolekar.ru
WHO monographs on selected medicinal plants - travolekar.ru WHO monographs on selected medicinal plants - travolekar.ru
Rhizoma Picrorhizae Definition Rhizoma Picrorhizae consists of the dried rhizome with root of Picrorhiza kurrooa Royle (1) or of Neopicrorhiza scrophulariiflora Hong [syn. Picrorhiza scrophulariiflora Pennell] (Scrophulariaceae) (2). Synonyms Picrorhiza kurrooa Royle: Picrorhiza kurroa Benth., P. kurroa Royle ex Benth. In the formularies and most references, the species is known as Picrorhiza kurroa Benth. or Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae), but according to the International Code of Botanical Nomenclature article 42, the correct name of the species should be Picrorhiza kurrooa Royle (3). Neopicrorhiza scrophulariiflora Hong: Picrorhiza scrophulariiflora Pennell. The rhizomes of Neopicrorhiza scrophulariiflora Hong [syn. Picrorhiza scrophulariiflora Pennell] are taxonomically similar and have been used in traditional medicine for the same purposes and traded under the same vernacular names (3). Selected vernacular names Balakadu len, hohwangryun, honglen, hunglen, honkadu, hú huáng lián, kadu, kadugurohini, kalikutki, karu picrorhiza, karru, katki, katu, katuka, katukaa, katuká, katuka rohini, katukarogani, katukarohini, katuki, katuko, katuku rohini, katurohini, katvi, kaur, khanekhaswael, kharbaqe-hindi, kot kaan phraao, koouren, kot kaanphraao, kour, kurri, kuru, kutaki, kutki, kutta, rohini, sutiktaka, tiktarohini, xi zanghu huang lian (1, 4–9). Geographical distribution Picrorhiza kurrooa Royle: native to the north-western Himalayas from Kashmir to Sikkim (1, 3, 4, 6). Neopicrorhiza scrophulariiflora Hong: found in the eastern Himalayas to the mountains of Yunan (3, 9). 258
Rhizoma Picrorhizae Description A perennial herb with a long rhizome. The leaves are basal and alternate, approximately 5–10 cm long. Spikes terminal. Calyx nearly equally in 5 segments. The corolla has 4 or 5 lobes, bilobiate with lobes more or less spreading or nearly actinomorphic. Stamens 4, inserted on corolla tube, slightly didynamous, as long as corolla or strongly exerted. Stigma capitate. Fruit an acute capsule, tapered at top, dehiscing first septicidally and then loculicidally into 4 valves, 12 mm long. Seeds numerous, ellipsoid: seed coat very thick, transparent and alveolate. Pollen grains spheroidal, 3-colpate, with partial or perforate tectum, the partial tectum microreticulate, colpus membrane smooth or sparsely granular (3, 10). The corolla of Picrorhiza kurrooa Royle is 4–5 mm long and 5-lobed, whereas the corolla of Neopicrorhiza scrophulariiflora is 9–10 mm long and 4-lobed (3). Plant material of interest: dried rhizome with root General appearance Rhizome: 2.5–12.0 cm long and 0.3–1.0 cm thick, subcylindrical, straight or slightly curved, externally greyish-brown, surface rough due to longitudinal wrinkles, circular scars of roots and bud scales and sometimes roots attached, tip ends in a growing bud surrounded by a tufted crown of leaves, in places cork exfoliates exposing dark cortex; fracture, short. Root: thin, cylindrical, 5–10 cm long and 0.5–1.0 mm in diameter, straight or slightly curved with a few longitudinal wrinkles and dotted scars, mostly attached with rhizomes, dusty grey, fracture short, inner surface black with whitish xylem (1, 2, 4). Organoleptic properties Odour: pleasant; taste: bitter (1). Microscopic characteristics The rhizome portion shows 20–25 layers of cork consisting of tangentially elongated, suberized cells; cork cambium 1–2-layered; cortex singlelayered or absent, primary cortex persists in some cases, 1 or 2 small vascular bundles present in the cortex. Vascular bundles surrounded by fibrous bundle sheath. Secondary phloem composed of parenchyma cells and a few scattered fibres. Cambium 2–4-layered. Secondary xylem consists of vessels, tracheids, fibres and parenchyma cells. Vessels vary in size and shape, have transverse oblique articulation; tracheids long, thickwalled, lignified, more or less cylindrical with blunt tapering ends. Starch grains abundant, 25–105 μm in diameter. Root portion, when young, 259
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Rhizoma Picrorhizae<br />
Descripti<strong>on</strong><br />
A perennial herb with a l<strong>on</strong>g rhizome. The leaves are basal and alternate,<br />
approximately 5–10 cm l<strong>on</strong>g. Spikes terminal. Calyx nearly equally in<br />
5 segments. The corolla has 4 or 5 lobes, bilobiate with lobes more or less<br />
spreading or nearly actinomorphic. Stamens 4, inserted <strong>on</strong> corolla tube,<br />
slightly didynamous, as l<strong>on</strong>g as corolla or str<strong>on</strong>gly exerted. Stigma capitate.<br />
F<strong>ru</strong>it an acute capsule, tapered at top, dehiscing first septicidally and<br />
then loculicidally into 4 valves, 12 mm l<strong>on</strong>g. Seeds numerous, ellipsoid:<br />
seed coat very thick, transparent and alveolate. Pollen grains spheroidal,<br />
3-colpate, with partial or perforate tectum, the partial tectum microreticulate,<br />
colpus membrane smooth or sparsely granular (3, 10).<br />
The corolla of Picrorhiza kurrooa Royle is 4–5 mm l<strong>on</strong>g and 5-lobed,<br />
whereas the corolla of Neopicrorhiza scrophulariiflora is 9–10 mm l<strong>on</strong>g<br />
and 4-lobed (3).<br />
Plant material of interest: dried rhizome with root<br />
General appearance<br />
Rhizome: 2.5–12.0 cm l<strong>on</strong>g and 0.3–1.0 cm thick, subcylindrical, straight<br />
or slightly curved, externally greyish-brown, surface rough due to l<strong>on</strong>gitudinal<br />
wrinkles, circular scars of roots and bud scales and sometimes<br />
roots attached, tip ends in a growing bud surrounded by a tufted crown<br />
of leaves, in places cork exfoliates exposing dark cortex; fracture, short.<br />
Root: thin, cylindrical, 5–10 cm l<strong>on</strong>g and 0.5–1.0 mm in diameter, straight<br />
or slightly curved with a few l<strong>on</strong>gitudinal wrinkles and dotted scars,<br />
mostly attached with rhizomes, dusty grey, fracture short, inner surface<br />
black with whitish xylem (1, 2, 4).<br />
Organoleptic properties<br />
Odour: pleasant; taste: bitter (1).<br />
Microscopic characteristics<br />
The rhizome porti<strong>on</strong> shows 20–25 layers of cork c<strong>on</strong>sisting of tangentially<br />
el<strong>on</strong>gated, suberized cells; cork cambium 1–2-layered; cortex singlelayered<br />
or absent, primary cortex persists in some cases, 1 or 2 small vascular<br />
bundles present in the cortex. Vascular bundles surrounded by<br />
fibrous bundle sheath. Sec<strong>on</strong>dary phloem composed of parenchyma cells<br />
and a few scattered fibres. Cambium 2–4-layered. Sec<strong>on</strong>dary xylem c<strong>on</strong>sists<br />
of vessels, tracheids, fibres and parenchyma cells. Vessels vary in size<br />
and shape, have transverse oblique articulati<strong>on</strong>; tracheids l<strong>on</strong>g, thickwalled,<br />
lignified, more or less cylindrical with blunt tapering ends. Starch<br />
grains abundant, 25–105 μm in diameter. Root porti<strong>on</strong>, when young,<br />
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