WHO monographs on selected medicinal plants - travolekar.ru

Cortex Phellodendron
Furthermore, an ethanol extract of the crude drug inhibited the activity
of cytochrome P450 in vitro, with an IC 50
of < 1% (65). Thus, concomitant
administration of the crude drug with a drug metabolized via
cytochrome P450 may affect drug metabolism (65).
Drug and laboratory test interactions
None reported.
Carcinogenesis, mutagenesis, impairment of fertility
A hot aqueous or methanol extract of the crude drug was not mutagenic at
a concentration of 100.0 mg/ml in the Ames test in Salmonella typhimurium
strains TA98 and TA100, or in Bacillus subtilis H-17 (Rec+) (66).
Berberine was not genotoxic in Saccharomyces cerevisiae assessed in
the SOS chromotest (67). No genotoxic activity was observed with or
without metabolic activation, and no cytotoxic or mutagenic effects were
seen under non-growth conditions. However, in dividing cells, the alkaloid
induced cytotoxic and cytostatic effects in proficient and repair-deficient
Saccharomyces cerevisiae. In dividing cells, the induction of frameshift
and mitochondrial mutations, as well as crossing over, showed that
the compound is not a potent mutagen (67).
Pregnancy: teratogenic effects
Intragastric administration of a 70% methanol extract of the dried bark to
pregnant rats, at a dose of 500.0 mg/kg bw daily from day 13 to the time
of delivery did not produce teratogenic effects in the offspring (68).
Pregnancy: non-teratogenic effects
Intragastric administration of a 70% methanol extract of the dried bark to
pregnant rats, at a dose of 500.0 mg/kg bw daily from day 13 to the time
of delivery, did not induce abortion or miscarriage (68).
Nursing mothers
Owing to the lack of safety data, the use of Cortex Phellodendron by
breastfeeding mothers is not recommended.
Paediatric use
No information was found.
Dosage forms
Crude drug and dried extracts, fluidextracts and tinctures. Store in a tightly
sealed container away from heat and light (3).
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