WHO monographs on selected medicinal plants - travolekar.ru

Cortex Phellodendron
Berberine
O
O
Jatrorrhizine
Palmatine
R = OH
R=OCH 3
OCH 3
R
H 3 CO
N +
H 3 CO
N +
OCH 3
OCH 3
H 3 CO
Phellodendrine
OH
HO
HO
H 3 CO
N + CH 3
H CH 3
Magnoflorine
HO
H 3 CO
H
N +
CH 3
OCH 3
Medicinal uses
Uses supported by clinical data
None.
Uses described in pharmacopoeias and well established documents
Used orally to treat abdominal pain, diarrhoea, gastroenteritis and urinary
tract infections (1, 15). While no clinical studies evaluating the safety
and efficacy of the crude drug have been reported, clinical studies have
been performed to assess the effects of berberine, the major chemical constituent
of the crude drug, for the treatment of diarrhoea, ocular trachoma
and cutaneous leishmaniasis. Berberine has been shown to be effective for
the treatment of bacterially-induced diarrhoea (16–21), ocular trachoma
and cutaneous leishmaniasis (22–24).
Uses described in traditional medicine
Treatment of burns, cough, fever, jaundice, malaria, skin wounds and
sores (5).
Pharmacology
Experimental pharmacology
An overview of the pharmacological studies evaluating the efficacy of the
crude drug and berberine, the major chemical constituent of the plant is
presented. The direct applicability of the pharmacological data for berberine
to the crude drug is uncertain and needs to be further investigated.
Antidiarrhoeal activity
The infectivity of rotavirus, a virus associated with the development of
diarrhoea, was inhibited in vitro by the addition of a decoction of the
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