WHO monographs on selected medicinal plants - travolekar.ru

Radix Panacis Quinquefolii
Two-way ANOVA showed that the main effects of treatment and administration
time were significant (p < 0.05). Glycaemia was lower over the last
45 minutes of the test after doses of 1, 2 or 3 g than after placebo (p < 0.05);
there were no significant differences between the three doses. The reductions
in the areas under the curve for these three doses were 14.4 ± 6.5%,
10.6 ± 4.0% and 9.1 ± 6%, respectively. Glycaemia in the last hour of the
test and area under the curve were lower when the crude drug was administered
40 minutes before the challenge than when it was administered 20,
10 or 0 minutes before the challenge (p < 0.05). Thus, doses of the crude
drug within the range of 1–3 g were equally effective (22).
Adverse reactions
No adverse reactions have been reported.
Contraindications
Radix Panacis Quinquefolii is contraindicated in cases of known allergy
or hypersensitivity to the plant material.
Warnings
No information available.
Precautions
Drug interactions
While no drug interactions have been reported, an extract of the root
(containing 10% ginsenosides) inhibited the activity of cytochrome
P450 isozymes CYP1A1, CYP1A2 and CYP1B1 in vitro in human liver
microsomes (45). Thus, there is a potential for interactions with other
drugs that are metabolized by these enzymes.
Radix Panacis Quinquefolii and its preparations may lower blood sugar
levels. Interactions with antidiabetic drugs are possible, but this subject
has not been sufficiently investigated.
Carcinogenesis, mutagenesis, impairment of fertility
At concentrations up to 36.0 mg/ml, neither an aqueous nor a butanol
extract of the crude drug was mutagenic in the Salmonella microsome assay
using S. typhimurium strain TM677 in the presence or absence of a
metabolic activating mix S9 (47).
Pregnancy: non-teratogenic effects
Due to a lack of safety data, use of the crude drug during pregnancy is not
recommended.
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