WHO monographs on selected medicinal plants - travolekar.ru

<strong>WHO</strong> <strong>monographs</strong> on selected medicinal plants
administered 0 g (placebo) or 3, 6 or 9 g of the ground crude drug in
capsules at 120, 80, 40 or 0 minutes before a 25 g oral glucose challenge.
Capillary blood glucose was measured before ingestion of the crude drug
or placebo and at 0, 15, 30, 45, 60, 90 and 120 minutes from the start of the
glucose challenge. Two-way analysis of variance (ANOVA) demonstrated
that treatment (0, 3, 6 and 9 g crude drug), but not time of administration
(120, 80, 40 or 0 min before the challenge) significantly affected postprandial
glucose (p < 0.05), with significant interaction for area under the
curve (p = 0.037). Pair-wise comparisons showed that compared with
administration of the placebo (0 g), doses of 3, 6 or 9 g of the crude drug
significantly (p < 0.05) reduced the area under the curve (by 19.7, 15.3 and
15.9%, respectively) and incremental glycaemia at 30 minutes (16.3, 18.4
and 18.4%, respectively), 45 minutes (12.5, 14.3 and 14.3%, respectively),
and 120 minutes (59.1, 40.9 and 45.5%, respectively) (20).
A preliminary short-term clinical study evaluated the efficacy of the
powdered crude drug on postprandial glycaemia in humans. On four separate
occasions, 10 subjects who did not have diabetes and nine subjects
who had type 2 diabetes mellitus were randomly allocated to receive 3.0 g
of the powdered root or placebo capsules, either 40 minutes before or
together with a 25.0 g oral glucose challenge. A capillary blood sample
was taken during fasting and then at 15, 30, 45, 60, 90 and 120 (only for
subjects with type 2 diabetes mellitus) minutes after the glucose challenge.
The results of this study demonstrated that in subjects who did not have
diabetes, there were no differences in postprandial glycaemia between the
subjects who received the placebo and those who received ginseng when
administered together with a glucose challenge. When powdered roots
were administered 40 minutes prior to the glucose challenge, significant
reductions were observed (p < 0.05). In subjects with type 2 diabetes mellitus,
the same was true whether capsules were taken before or together
with the glucose challenge (p < 0.05). The reductions in the area under the
glycaemic curve were 18% ± 31% for subjects who did not have diabetes
and 19 ± 22% and 22 ± 17% for subjects with type 2 diabetes mellitus
when capsules were administered before or together with the glucose
challenge, respectively (21).
A randomized, cross-over study to assess whether a dose of the powdered
root of < 3.0 g, administered 40 minutes prior to an oral glucose challenge
would reduce postprandial glycaemia in subjects without diabetes
was performed. Twelve healthy volunteers received treatment: 0 (placebo),
1, 2 or 3.0 g of the crude drug at 40, 20, 10 or 0 minutes prior to a 25.0 g oral
glucose challenge. Capillary blood was collected before administration and
at 0, 15, 30, 45, 60 and 90 minutes after the start of the glucose challenge.
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