WHO monographs on selected medicinal plants - travolekar.ru

<strong>WHO</strong> <strong>monographs</strong> on selected medicinal plants
Again, no significant effect on any of the three above-mentioned night
vision tests was found (42).
Another double-blind, placebo-controlled, cross-over study conducted
on US Navy SEALs personnel investigated the effect of bilberry on
night visual acuity and night contrast sensitivity. The test subjects were
young men with good vision; eight received a placebo and seven received
active capsules containing 160 mg of bilberry extract (25%) for 3 weeks.
After the 3-week treatment period, a 1-month washout period was used
to allow any effect of bilberry on night vision to dissipate. In the second
3-week treatment period, the eight subjects who first received the placebo
were given active capsules, and the seven who first received active capsules
were given the placebo. Night visual acuity and night contrast sensitivity
were again tested throughout the 3-month experiment. The results
of this investigation showed no difference in night visual acuity during
any of the measurement periods when examining the average night visual
acuity or the last night visual acuity measurement during active and placebo
treatments. In addition, there was no difference in night contrast
sensitivity during any of the measurement periods when examining the
average night contrast sensitivity or the last night contrast sensitivity
measurement during active and placebo treatments (36).
Premenstrual syndrome and dysmenorrhoea
In a randomized, double-blind, placebo-controlled clinical trial the efficacy
of a fruit extract containing anthocyanosides on the symptoms of
dysmenorrhoea associated with premenstrual syndrome was assessed.
Women with primary dysmenorrhoea received either the extract corresponding
to 115 mg anthocyanosides per day or a placebo for 5 days beginning
3 days before menstruation for two consecutive cycles. A significant
improvement in pelvic/lumbosacral pain (p < 0.01), mammary tension
(p < 0.01), nausea (p < 0.01), and heaviness of the lower limbs (p < 0.01)
was reported as compared with the baseline (11).
Venous insufficiency and varicose veins
The ability of an extract of the crude drug containing anthocyanins to
improve symptoms associated with varicosities and telangiectases was assessed.
Twenty-seven patients with varices, varicosities and telangiectases
were treated orally with 4–6 tablets, equivalent to 100–150 mg anthocyanins
daily for 10–15 days per month for 2 months. An improvement in a
variety of symptoms was observed including a reduction in bruising (12).
In one study in humans, oral administration of a crude drug extract containing
anthocyanins (dose not stated) to patients with varicose veins and
ulcerative dermatitis reduced capillary leakage (16). The biochemical and
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