WHO monographs on selected medicinal plants - travolekar.ru

<strong>WHO</strong> <strong>monographs</strong> on selected medicinal plants
crease capillary permeability and fragility (26). In one study, the initial
phase of renal hypertension induced by ligature of the abdominal aorta
was accompanied by a transient increase in vascular permeability. This
increase in permeability is higher in the skin and in the aorta wall than in
the blood vessels of the brain. Treatment of rats with anthocyanins from
the crude drug (dose not stated) for 12 days prior to the induction of hypertension
kept the blood–brain barrier permeability normal and limited
the increase in vascular permeability in the skin and the aorta wall (28). In
cholesterol-fed rabbits, administration of anthocyanidins from the crude
drug (dose not stated) did not modify the serum cholesterol levels, but
decreased the proliferation of the intima; the extracellular matrix production;
the deposition of calcium and lipid in the aorta; and decreased the
DNA and lipid contents. Alteration in the biochemical composition of
the isolated brain microvessels was also diminished. The suggested mechanism
of action may be through an interaction of the anthocyanins with
collagen, increasing the cross-linking and thus diminishing the permeability
of small, as well as of large, blood vessels (29).
The effects of anthocyanosides from the fruit on capillary filtration in
diabetic rats were assessed. Rats with streptozotocin-induced diabetes
were randomly allocated to one of three groups to receive either Ginkgo
biloba (group A), the crude drug (group B) or no treatment (group C).
The isotopic test of capillary filtration consisted of intravenously injecting
99 mtechnetium-labelled albumin, inducing venous compression on a
hindquarter, and measuring radioactivity externally on the limb before,
during and after removal of venous compression. Interstitial albumin retention
and the ratio of the amplitudes of the low- and high-frequency
peaks (LF/HF ratio), an index of lymphatic function obtained by the fast
Fourier transform of the last part of the radioactivity curve, were calculated.
In streptozotocin-treated animals, the isotopic test was performed
at a mean age of 97 days (time 1) and after 6 weeks (time 2) and 12 weeks
(time 3) of treatment (6 and 12 weeks after time 1). At time 1, albumin
retention was significantly higher in the three groups of diabetic rats than
in the control rats, with no significant difference between these groups. In
group B, albumin retention decreased significantly at times 2 and 3
(p = 0.015). In group C, albumin retention increased significantly from
time 1 to time 3 (p < 0.0005). In group A, albumin retention increased
slightly (not statistically significantly) between time 1 and time 3. In
groups A and C, the LF/HF ratio significantly increased with time
(p < 0.0005) and the levels at time 3 were significantly higher than those in
control rats (p < 0.0001). In group B, the LF/HF ratio remained unchanged
from time 1 to time 3 and was similar to the values found in the control
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