WHO monographs on selected medicinal plants - travolekar.ru

<strong>WHO</strong> <strong>monographs</strong> on selected medicinal plants
constituent is the isoquinoline alkaloid, magnocurarine (0.15–0.23%).
The presence of liriodendrine has also been reported. The bark also contains
an essential oil, the major constituents of which are cadinol (14%),
1,4-cineole (6%), p-cymene (8%), and -eudesmol (17%) and geraniol
(9%), among others (8, 15–18). The structures of magnolol, honokiol and
magnocurarine are presented below.
Honokiol
H 2 C
H 2 C
OH
OH
Magnolol
H 2 C
HO
OH
Magnocurarine
H CH 3
HO
N + CH 3
CH 2 H 3 CO
OH
Medicinal uses
Uses supported by clinical data
No information was found.
Uses described in pharmacopoeias and well established documents
Used orally for the treatment of gastrointestinal disorders such as constipation,
dyspepsia, gastritis, nausea and vomiting. Also used orally to treat
anxiety, coughs and shortness of breath (2).
Uses described in traditional medicine
Treatment of allergic rhinitis, headache, lack of appetite, respiratory congestion,
neurosis and fever, and as a uterine stimulant (6, 8, 19, 20).
Pharmacology
Experimental pharmacology
Since no clinical studies have directly evaluated Cortex Magnoliae for any
therapeutic condition and very few pharmacological studies have been
conducted on extracts of the bark, most of this section describes the pharmacology
and clinical studies of the major chemical constituents, particularly
magnolol. The correlation of these data to the crude drug or its extracts
requires further investigation.
Anti-allergic activity
Oral administration of 0.01–1.0 g/kg body weight (bw) of an aqueous
extract of the bark dose-dependently inhibited compound 48/80-induced
systemic anaphylaxis in rats (21). At the same dose, the aqueous extract
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