WHO monographs on selected medicinal plants - travolekar.ru

Fructus Macrocarponii
rin was reported in a 69-year-old male patient with a mitral valve replacement
(49). The patient was ingesting 2 l of cranberry juice per day in addition
to warfarin and his INR ranged between 8 and 11. The patient was
advised to stop drinking cranberry juice and his INR returned to 3 (normal)
after 3 days.
The Medicines and Healthcare Products Regulatory Agency (MHPRA)
in the United Kingdom has reported numerous cases of a possible interaction
between cranberry juice and warfarin, leading to changes in the INR or
to bleeding. In four cases, the increase in the INR or bleeding was not
significant. Two cases of an unstable INR and one case of a decreased INR
were reported (48).
Carcinogenesis, mutagenesis, impairment of fertility
No information was found.
Other precautions
No information was found.
Dosage forms
Crude drug, extracts, juice, tablets, capsules. Store in a well-closed container,
in a refrigerator (2).
Posology
(Unless otherwise indicated)
For the prevention of UTIs in adults the recommended daily dose of cranberry
juice is 30–300 ml of a 30% pure juice product; for the treatment of
UTIs in adults the daily dosage range is 360–960 ml or equivalent (1).
Capsules containing a concentrated cranberry extract: 1–6 capsules
daily, equivalent to 3 fluid ounces (90 ml) cranberry juice or 400–450 mg
cranberry solids (1).
References
1. Upton R, Graff A, Swisher D, eds. Cranberry fruit. Vaccinium macrocarpon
Aiton. In: American herbal pharmacopeia. Santa Cruz, CA, American Herbal
Pharmacopeia, 2002.
2. The United States Pharmacopeia. 29. Rockville, MD, United States Pharmacopeia
Convention, 2005.
3. Farnsworth NR, ed. NAPRALERT database. Chicago, University of Illinois
at Chicago, IL (an online database available directly through the University
of Illinois at Chicago or through the Scientific and Technical Network [STN]
of Chemical Abstracts Services), 30 June 2005.
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