WHO monographs on selected medicinal plants - travolekar.ru

Fructus Macrocarponii
Medicinal uses
Uses supported by clinical data
Orally as adjunct therapy for the prevention and symptomatic treatment
of urinary tract infections in adults (8–20). Two clinical trials have assessed
the effect of the fruit juice in paediatric populations (17, 21), but
the results were negative. Results from clinical trials involving the use of
cranberry for the treatment of children with neurogenic bladder were also
negative and do not support the use of cranberry products in paediatric
populations (22).
Uses described in pharmacopoeias and well established documents
No information was found.
Uses described in traditional medicine
Treatment of asthma, fever, loss of appetite, scurvy and stomach ailments,
as well as gallbladder and liver disease and for treatment of wounds (3, 23).
Pharmacology
Experimental pharmacology
Antimicrobial and antiadhesive activity
A concentrated extract of the juice of the crude drug was tested for activity
against the following pathogens: Alcaligenes faecalis, Clostridium perfringens,
Enterococcus faecalis, Escherichia coli, Mycobacterium phlei,
Pseudomonas aeruginosa, Salmonella california, Salmonella enteritidis,
Salmonella typhimurium, Shigella sonnei, Staphylococcus aureus and methicillin-resistant
S. aureus, as well as Candida albicans. The crude drug
concentrate did not inhibit the growth of C. albicans, but had variable
activity against the bacteria at dilutions of 1:5 and 1:10 (24).
Early investigations of the mechanism of cranberry’s bacteriostatic activity
suggested that acidification of the urine may be responsible for its
activity. However, more recent studies have demonstrated that urinary
acidification is not the mechanism by which cranberry exerts its effects,
but it does so through a mechanism that involves the inhibition of bacterial
adherence (25–27). In vitro studies have shown that, in the 77 clinical
isolates tested, cranberry juice decreased bacterial adherence of E. coli to
uroepithelial cells by 60% when compared with saline solution (28). Furthermore,
cranberry juice inhibited the adherence of E. coli to human urinary
epithelial cells three times more stongly than E. coli isolated from
other clinical sources (27, 28). One study demonstrated that cranberry
juice dose-dependently inhibited the haemagglutination activity of E. coli
urinary isolates expressing type I and P adhesion (27).
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