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Current Trends in Biotechnology and Pharmacy Vol. 5 (3) 1251-1272 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online) 1271 Taxonomy, fermentation, isolation and characterization. J Antibiot (Tokyo), 44:1342-1347. 68. Ihara, M., Ishikawa, K., Fukuroda, T., Saeki, T., Funabashi, K., Fukami, T., Suda, H. and Yano, M. (1992). In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ET A receptor. J Cardiovasc Pharmacol., 20: S11-14. 69. Fukami, T., Yamakawa, T., Niiyama, K., Kojima, H., Amano, Y., Kanda, F., Ozaki, S., Fukuroda, T., Ihara, M., Yano, M. and Ishikawa, K. (1996). Synthesis and structure-activity relationships of 2- substituted D-tryptophan-containing peptidic endothelin receptor antagonists: importance of the C-2 substituent of the D- tryptophan residue for endothelin A and B receptor subtype selectivity. J Med Chem., 39: 2313-2330. 70. Hochlowski, J.E., Hill, P., Whittern, D.N., Scherr, M.H., Rasmussen, R.R., Dorwin, S.A. and McAlpine, J.B. (1994). Aselacins, novel compounds that inhibit binding of endothelin to its receptor. II. Isolation and elucidation of structures. J Antibiot (Tokyo), 47: 528-535. 71. Jackson, M., Burres, N.S., Karwowski, J.P., Alder, L.A., Humphrey, P.E., Kohl, W.L. and McAlpine, J.B. (1994). Aselacins, novel compounds that inhibit binding of endothelin to its receptor. I. The producing organism, fermentation and biological activity. J Antibiot (Tokyo), 47: 523-527 72. Fujimoto, M., Mihara, S., Nakajima, S., Ueda, M., Nakamura, M. and Sakurai, K. (1992). A novel non-peptide endothelin antagonist isolated from bayberry, Myrica cerifera. FEBS Lett., 305: 41-44. 73. Maguire, J., Bacon, C., Fujimoto, M. and Davenport, A. (1994). Myricerone caffeoyl ester (50-235) is a non-peptide antagonist selective for human ET A receptors. J Hypertens., 12: 675-680. 74. Ohshima, T., Hirata, M., Oda, T., Sasaki, A. and Shiratsuchi, M. (1994). Pheophorbide a, a potent endothelin receptor antagonist for both ET A and ET B subtypes. Chem Pharm Bull., 42: 2174- 2176. 75. Caballero-George, C., Vanderheyden, P.M.L., Solis, P.N., Pieters, L., Shahat, A.A., Gupta, M.P., Vauquelin, G. and Vlietinck, A. (2001). Biological screening of selected medicinal Panamanian plants by radioligand-binding techniques. Phytomedicine, 8: 59-70. 76. Caballero-George, C., Vanderheyden, P.M.L., Okamoto, Y., Masaki, T., Mbwambo, Z., Apers, S., Gupta, M.P., Pieters, L., Vauquelin, G. and Vlietinck, A. (2004). Evaluation of bioactive saponins and triterpenoidal aglycons for the binding properties on human endothelin ET A and angiotensin AT 1 receptors. Phytotherapy Research, 18: 729-736. 77. Gulavita, N.K., Wright, A.E., McCarthy, P.J., Pomponi, S.A., Kelly-Borges, M., Chin, M. and Sills, M.A. (1993). Isolation and structure elucidation of 34- Sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella. Journal of Natural Products, 56: 1613-1617. 78. Gao, J., Caballero-George, C., Wang, B., Rao, K.V., Shilabin, A.G. and Hamann, M.T. (2009). 5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for Catherina Caballero-George
Current Trends in Biotechnology and Pharmacy Vol. 5 (3) 1251-1272 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online) 1272 NorKA to the human neuropeptide Y Y 1 receptor. J Nat Prod., 72: 2172-2176. 79. Corder, R., Douthwaite, J.A., Lees, D.M., Khan, N.Q., Viseu dos Santos, A., Wood, E., Carrier, M. (2000). Endothelin-1 synthesis reduced by red wine. Nature, 414: 863-864 80. Kim-Park, S., Ku, D.D. (2000). Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Clinical and Experimental Pharmacology and Physiology. 27: 780-786 81. Zhang, T., Cui, B., Dai, D., Su, W. (2005). CPU 86017, p- chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway. Acta Pharmacologica Sinica, 26: 1309–1316. 82. Taylor, M.W., Radax, R., Steger, D. and Wagner, M. (2007). Sponge-associated microorganisms: evolution, ecology, and biotechnological potential. Microbiology and Molecular Biology Reviews, 71: 295- 347. 83. Del Sol Jiménez, M., Garzón, S.P. and Rodríguez, A.D. (2003). Plakortides M and N, bioactive polyketide endoperoxides from the Caribbean marine sponge Plakortis halichondrioides. J Nat Prod, 66: 655-661. 84. Rumalla, C.S., Ali, Z., Weerasooriya, A.D., Smillie, T.J. and Khan, I.A. (2010). Two new triterpene glycosides from Centella asiatica. Planta Med, 76: 1018-1021. 85. Laszczyk, M., Jäger, S., Simon-Haarhaus, B., Scheffler, A. and Schempp, C.M. (2006). Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (Betulae cortex). Planta Med., 72: 1389-1395. 86. Lin, K.W., Huang, A.M., Tu, H.Y., Lee, L.Y., Wu, C.C., Hour, T.C., Yang, S.C., Pu, Y.S. and Lin, C.N. (2011). Xanthine oxidase inhibitory triterpenoid and phloroglucinol from guttiferaceous plants inhibit growth and induced apoptosis in human NTUB1 cells through a ROSdependent mechanism. J Agric Food Chem, 59: 407-414. 87. Csapi, B., Hajdú, Z., Zupkó, I., Berényi, A., Forgo, P., Szabó, P. and Hohmann, J. (2010). Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria. Phytother Res, 24: 1664-1669. Does nature has the cure for hypertension
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(December 7-9, 2011) Venue: Karunya
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