full issue - Association of Biotechnology and Pharmacy
full issue - Association of Biotechnology and Pharmacy
full issue - Association of Biotechnology and Pharmacy
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Current Trends in <strong>Biotechnology</strong> <strong>and</strong> <strong>Pharmacy</strong><br />
Vol. 5 (3) 1362-1371 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online)<br />
1369<br />
Fig. 5. Effects <strong>of</strong> Chlor<strong>of</strong>orm <strong>and</strong> ethanol extracts <strong>of</strong> root<br />
<strong>of</strong> X. strumarium on total triglyceride <strong>and</strong> very low density<br />
lipids levels in triton- induced hyperlipidemic<br />
metabolic processes involving redox enzymes<br />
<strong>and</strong> bioenergetics electron transfer .Owing to the<br />
ROS overproduction <strong>and</strong>/or inadequate<br />
antioxidant defense, there is upsurge <strong>of</strong> ROS <strong>and</strong><br />
this culminates in oxidative stress. It is quite<br />
interesting to note that plants have good<br />
antioxidant ability <strong>and</strong> are safer than the synthetic<br />
antioxidants . The antioxidant activity can be<br />
attributed to various mechanisms like prevention<br />
<strong>of</strong> chain initiation, binding <strong>of</strong> transition metal<br />
ion catalysts, decomposition <strong>of</strong> peroxides,<br />
reductive capacity, <strong>and</strong> radical scavenging<br />
activity (4).<br />
In the present study, five different<br />
antioxidant methods for evaluation <strong>of</strong> antioxidant<br />
activity have been used. Ethanol <strong>and</strong> chlor<strong>of</strong>orm<br />
extracts <strong>of</strong> X. Strumarium root produced<br />
significant antioxidant activity. This can be<br />
attributed to the flavonoids <strong>and</strong> other phytoconstituents<br />
present in the extracts, similar lipid<br />
lowering activity was also observed in the leaf<br />
extracts <strong>of</strong> A.marmelos which may be attributed<br />
to the phyto-chemical constituents present in it,<br />
such as flavonoids, saponins <strong>and</strong> phenolic<br />
ingredients as reported (15-16). Hyperlipidemia<br />
is one <strong>of</strong> the important risk factors involved in<br />
the development <strong>of</strong> cardiovascular diseases (17).<br />
Increase HDL levels <strong>and</strong> reduction in LDL shows<br />
the intensive conversion <strong>of</strong> LDL to HDL <strong>and</strong><br />
clearance <strong>of</strong> circulating lipids. Total cholesterol/<br />
HDL-C ratio <strong>of</strong> >4.5 is associated with increased<br />
coronary heart disease (CHD) risk <strong>and</strong> the ideal<br />
ratio is