full issue - Association of Biotechnology and Pharmacy

Current Trends in Biotechnology and Pharmacy
Vol. 5 (3) 1362-1371 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online)
1367
Fig. 2. Comparison of Total reducing power, Nitric Oxide
and Super-oxide scavenging activity of 100mcg/ml of AA,
BHA, Alcohol and Chloroform Extract of the root of X.
6 hr
24 hr
48 hr
Fig. 4. Effects of Chloroform and ethanol extracts of root
of X.strumarium on total cholesterol and low density lipids
levels in triton-induced hyperlipidemic rats
Fig. 3. Comparison of Total reducing power, Nitric Oxide
and Super-oxide scavenging activity of 500mcg/ml of AA,
BHA, Alcohol and Chloroform Extract of the root of
X. strumarium
inhibited by BHA (standard) and extracts from
100µg/ml. Both the extracts produced significant
superoxide radical scavenging activity in a
concentration-dependent manner. Chloroform
extract showed the lowest IC value (418 ± 4.15)
50
which is better than BHA (415.14 ± 5.98).
Antihyperlipidemic activity: The non ionic
detergent, Triton WR-1339, has been widely used
to block the uptake of triacyl glycerol rich
lipoprotein from plasma by peripheral tissues in
order to produce acute hyperlipidemia in animal
models which are often used for a number of
objectives. The parenteral administration of
Triton induces hyperlipidemia in adult rats,
where the blood cholesterol and triglycerides
levels were reached maximum in 20hrs, followed
by a decline to normal values (12-14).
Administration of Triton resulted in increase in
serum levels of cholesterol, triglycerides, VLDL,
and LDL. A significant reversal in serum levels
of cholesterol, triglycerides, VLDL, and LDL
levels was noticed in the animals treated with X.
strumarium root extracts when compared with
the control group (Table-3). Simvastatin
(standard) produced maximum cholesterol- and
LDL-lowering effect at both 6 h and 24 h. ethanol
extract 200 and Chloroform extract 400 produced
a significant decrease in serum cholesterol and
Sridharamurthy et al