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Current Trends in Biotechnology and Pharmacy Vol. 5 (3) 1353-1361 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online) 1361 that central processing unit (CPU) utilization is found to be varying between 97 to 32 % with an average of 65% consumption where as memory utilization is very steady with an average of 37% consumption. The new database server is hosted on HP UNIX. From figure 5, it is clear that the average CPU utilization has dropped to 17.5% and average memory utilization to 5% even after Fig. 5. CPU and Memory Utilization of the new db server adding additional databases for new applications like SiteScope, CAE and HP TRIM. Therefore, the server on the new platform offers more scalability and manageability besides taking care of all future requirements of the Labs under study for the next decade. Conclusion The ability to replicate the most critical systems on a continuous basis has been a huge win for the business. Majority of the disaster recovery systems are available as hot backups to the production system at a primary data center. The primary goal of CRO under study is addressed i.e. data storage and retrieval as stored and making systems highly available for data access. The new implementation will benefit the customers as the data access continues to be available even if the entire site goes down. The new implementation with leading edge technologies will help CRO under study to attract more customers, which benefits its investors ultimately. Acknowledgement We gratefully acknowledge the support of all members of Vimta Labs especially Mr. Harriman, Director (Technical) for his advice and encouragement in preparing this paper. We are thankful to all other websites for providing the valuable information on data center virtualization. References 1. Source: for Vimta Labs information – www.vimta.com 2. Source: for VMware - www.vmware.com 3. Source: for HP products - www.hp.com 4. Source: for Waters products - www.waters.com Information Technology Consolidation with Virtualization
Current Trends in Biotechnology and Pharmacy Vol. 5 (3) 1362-1371 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online) In-vitro Antioxidant and Antilipidemic Activities of Xanthium strumarium L. N.B.Sridharamurthy 1 *, R. Yogananda 2 and Srinivas U. 3 1 Department of Pharmacology, Dayananda Sagar College of Pharmacy, Bangalore, India 2 Department of Pharmaceutics, SJM college of Pharmacy, Chitradurga, India 3 Department of Pharmacognosy, Srinivasa College of Pharmacy, Mangalore, India *For Correspondence - murthy.sridhara@yahoo.com 1362 Abstract In the present study Chloroform and alcohol extracts of Xanthium strumarium L. were evaluated for in vitro antioxidant and antilipidemic activity by various methods namely total reducing power, scavenging of free radicals such as 1,2-diphenyl-2-picrylhydrazyl (DPPH), super oxide, nitric oxide, and hydrogen peroxide. The percentage scavenging of various free radicals were compared with standard antioxidants such as ascorbic acid and Butylated hydroxyl toluene (BHT). The extracts were also evaluated for anti-lipidemic activity in Triton WR-1339 (iso-octyl polyoxyethylene phenol)- induced hyperlipidemia in Swiss albino rats by estimating serum triglyceride, very low density lipids (VLDL), cholesterol, low-density lipids (LDL), and high-density lipid (HDL) levels. Significant antioxidant activity was observed in all the methods, significant reduction (P < 0.01) in cholesterol at 6 and 24 h and (P < 0.05) at 48 h. There was significant reduction (P < 0.01) in triglyceride level at 6, 24, and 48 h. The VLDL level was also significantly (P < 0.05) reduced from 24 h and maximum reduction (P < 0.01) was seen at 48 h. There was significant increase (P < 0.01) in HDL at 6, 24, and 48 h. From the results; it is evident that alcohol and chloroform extracts of X. strumarium can effectively decrease plasma cholesterol, triglyceride, LDL, and VLDL and increase plasma HDL levels. Keywords: Anti-lipidemic, antioxidant, X. strumarium, triton Introduction Oxidation is one of the destructive processes, wherein it breaks down and damages various molecules. Oxygen via its transformation produces reactive oxygen species (ROS) such as super oxide, hydroxyl radicals, and hydrogen peroxide. They provoke uncontrolled reactions (1). Molecular oxygen is an essential component for all living organisms, but all aerobic species suffer from injury if exposed to concentration more than 21% (2). Free radicals attack and induce oxidative damage to various bio-molecules including proteins, lipids, lipoproteins, and DNA. The body possesses several defense systems comprising enzymes and radical scavengers. Some of them constitute the repair systems for bio-molecules that are damaged by the attack of free radicals (2, 3). An excessive and/or sustained increase in ROS production has been implicated in the pathogenesis of cancer, diabetes mellitus, In-vitro antioxidant and antilipidemic activities of Xanthium strumarium L.
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