full issue - Association of Biotechnology and Pharmacy

Current Trends in Biotechnology and Pharmacy
Vol. 5 (3) 1338 -1345 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online)
1344
pyruvate concentrations. Because the
equilibrium constant of the lactate
dehydrogenase reaction markedly favors lactate
over pyruvate, small increases in pyruvate
concentration will result in large increases in
lactate concentration.
Conclusion
In the light of the results obtained, it
appears that energy depletion in relation to body
fuel uses and gluconeogenic precursor
availability increases the ability of the intestine
to absorb glucose from its lumen and stimulates
intestinal gluconeogenesis. In phase III fasting,
there is an increased catabolism of proteins and
in the absence of GLUT2, Glucose 6
Phosphsatase could also play a role in glucose
transport through the cell and thereby, in its
secretion into the bloodstream. From the above
mentioned data, it is clear that small intestine
serves as a gluconeogenic organ by providing
substrates needed for hepatic gluconeogenesis.
Acknowledgement
The authors gratefully thank MAHER
University, Chennai for giving financial support
for completing this work.
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