full issue - Association of Biotechnology and Pharmacy
full issue - Association of Biotechnology and Pharmacy
full issue - Association of Biotechnology and Pharmacy
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Current Trends in <strong>Biotechnology</strong> <strong>and</strong> <strong>Pharmacy</strong><br />
Vol. 5 (3) 1338 -1345 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online)<br />
1344<br />
pyruvate concentrations. Because the<br />
equilibrium constant <strong>of</strong> the lactate<br />
dehydrogenase reaction markedly favors lactate<br />
over pyruvate, small increases in pyruvate<br />
concentration will result in large increases in<br />
lactate concentration.<br />
Conclusion<br />
In the light <strong>of</strong> the results obtained, it<br />
appears that energy depletion in relation to body<br />
fuel uses <strong>and</strong> gluconeogenic precursor<br />
availability increases the ability <strong>of</strong> the intestine<br />
to absorb glucose from its lumen <strong>and</strong> stimulates<br />
intestinal gluconeogenesis. In phase III fasting,<br />
there is an increased catabolism <strong>of</strong> proteins <strong>and</strong><br />
in the absence <strong>of</strong> GLUT2, Glucose 6<br />
Phosphsatase could also play a role in glucose<br />
transport through the cell <strong>and</strong> thereby, in its<br />
secretion into the bloodstream. From the above<br />
mentioned data, it is clear that small intestine<br />
serves as a gluconeogenic organ by providing<br />
substrates needed for hepatic gluconeogenesis.<br />
Acknowledgement<br />
The authors grate<strong>full</strong>y thank MAHER<br />
University, Chennai for giving financial support<br />
for completing this work.<br />
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