full issue - Association of Biotechnology and Pharmacy
full issue - Association of Biotechnology and Pharmacy
full issue - Association of Biotechnology and Pharmacy
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Current Trends in <strong>Biotechnology</strong> <strong>and</strong> <strong>Pharmacy</strong><br />
Vol. 5 (3) 1318 -1324 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online)<br />
differentiation <strong>of</strong> cellular systems <strong>of</strong> parasites<br />
which are nonetheless unique for their survival<br />
<strong>and</strong> hence they are considered as avenues for<br />
drug/lig<strong>and</strong> targets. Furthermore, the s<strong>of</strong>tware<br />
tools for homology modelling, simulations <strong>and</strong><br />
structure-based virtual screening <strong>and</strong> on-line<br />
databases are in turn enhancing the rapid<br />
developments in building the repertoire <strong>of</strong> the<br />
receptor <strong>and</strong> lig<strong>and</strong> libraries. Therefore, in the<br />
present study, the chosen inhibitors viz.,<br />
ampicillin, amoxicillin, ceftriaxone, cefotaxime,<br />
cefepime, meropenem, <strong>and</strong> calvulanic acid were<br />
made to bind in the active site <strong>of</strong> PBP-1A. Of<br />
which, ampicillin has a good docking score<br />
(Table-1) <strong>and</strong> thus, ampicillin is considered as<br />
the best inhibitor for PBP-1A <strong>of</strong> HI (Francis et<br />
al., 2003). The Pre-ADME properties <strong>of</strong><br />
ampicillin (Table-2) are coinciding with the<br />
results <strong>of</strong> Sarah et al., (16).<br />
Acknowledgment<br />
One <strong>of</strong> the authors (SK) greatly<br />
acknowledges DBT, Govt. <strong>of</strong> India for providing<br />
Bioinformatics Infrastructural Facility.<br />
References<br />
1. Jeffery Errington, Richard, A. Daniel <strong>and</strong><br />
Dirk-Jan Scheffers. (2003). Cytokinesis in<br />
Bacteria. Microbiol Mol Biol Rev.67(1);<br />
52-65.<br />
2. Jothi, R., Przytycka, T.M. <strong>and</strong> Aravind L.<br />
(2007). Discovering functional linkages<br />
<strong>and</strong> uncharacterized cellular pathways<br />
using phylogenetic pr<strong>of</strong>ile comparisons: a<br />
comprehensive assessment. BMC<br />
Bioinformatics, 8:173.<br />
3. Robert D. Fleischmann, Mark D. Adams,<br />
Owen White <strong>and</strong> Rebecca A. Clayton.<br />
(1995). Whole-Genome R<strong>and</strong>om<br />
Sequencing <strong>and</strong> Assembly <strong>of</strong> Haemophilus<br />
influenzae Rd. Science. 269: 496-512.<br />
1323<br />
4. Chambers, H. F. (1999) Penicillin-binding<br />
protein-mediated resistance in<br />
pneumococci <strong>and</strong> staphylococci. The<br />
Journal <strong>of</strong> Infectious Diseases. 179: S353-<br />
S359.<br />
5. Venkatesan, S. K., Shukla, A. K. <strong>and</strong><br />
Dubey, V. K. (2010). Molecular docking<br />
studies <strong>of</strong> selected tricyclic <strong>and</strong> quinine<br />
derivatives on trypanothione reductase <strong>of</strong><br />
Leishmania infantum. J. Comp. Chem. 31<br />
(13):2463-2474.<br />
6. Saravanan, P., Venkatesan, S. K., Mohan,<br />
C. G., Patra, S. <strong>and</strong> Dubey V. K. (2010)<br />
Mitogen-activated protein kinase 4 <strong>of</strong><br />
Leishmania parasite as a therapeutic target.<br />
Eur. J. Med. Chem. 45, 5662-5670.<br />
7. Jean van Heijenoort. (2007). Lipid<br />
Intermediates in the Biosynthesis <strong>of</strong><br />
Bacterial Peptidoglycan. Microbiol Mol<br />
Biol Rev. 71(4): 620–635.<br />
8. Adeline Derouaux, Benoît Wolf, Claudine<br />
Fraipont, Eefjan Breukink, Martine<br />
Nguyen-Distèche <strong>and</strong> Mohammed Terrak.<br />
(2008). The Mon<strong>of</strong>unctional<br />
Glycosyltransferase <strong>of</strong> Escherichia coli<br />
Localizes to the Cell Division Site <strong>and</strong><br />
Interacts with Penicillin-Binding Protein.<br />
J Bacteriol. 190(5): 1831–1834.<br />
9. Shide Liang, Samy O. Meroueh, Guangce<br />
Wang, Chao Qiu <strong>and</strong> Yaoqi Zhou. (2010).<br />
Consensus scoring for enriching nearnative<br />
structures from protein-protein<br />
docking decoys. Proteins. 1; 75(2): 397–<br />
403.<br />
10. Pamela J. Yeh, Matthew J. Hegreness,<br />
Aviva Presser Aiden <strong>and</strong> Roy Kishony.<br />
(2009). Drug interactions <strong>and</strong> the evolution<br />
<strong>of</strong> antibiotic resistance. Nature Reviews<br />
Microbiology 7: 460-466.<br />
Ramya Jyothi et al