full issue - Association of Biotechnology and Pharmacy

Current Trends in Biotechnology and Pharmacy
Vol. 5 (3) 1318 -1324 July 2011, ISSN 0973-8916 (Print), 2230-7303 (Online)
differentiation of cellular systems of parasites
which are nonetheless unique for their survival
and hence they are considered as avenues for
drug/ligand targets. Furthermore, the software
tools for homology modelling, simulations and
structure-based virtual screening and on-line
databases are in turn enhancing the rapid
developments in building the repertoire of the
receptor and ligand libraries. Therefore, in the
present study, the chosen inhibitors viz.,
ampicillin, amoxicillin, ceftriaxone, cefotaxime,
cefepime, meropenem, and calvulanic acid were
made to bind in the active site of PBP-1A. Of
which, ampicillin has a good docking score
(Table-1) and thus, ampicillin is considered as
the best inhibitor for PBP-1A of HI (Francis et
al., 2003). The Pre-ADME properties of
ampicillin (Table-2) are coinciding with the
results of Sarah et al., (16).
Acknowledgment
One of the authors (SK) greatly
acknowledges DBT, Govt. of India for providing
Bioinformatics Infrastructural Facility.
References
1. Jeffery Errington, Richard, A. Daniel and
Dirk-Jan Scheffers. (2003). Cytokinesis in
Bacteria. Microbiol Mol Biol Rev.67(1);
52-65.
2. Jothi, R., Przytycka, T.M. and Aravind L.
(2007). Discovering functional linkages
and uncharacterized cellular pathways
using phylogenetic profile comparisons: a
comprehensive assessment. BMC
Bioinformatics, 8:173.
3. Robert D. Fleischmann, Mark D. Adams,
Owen White and Rebecca A. Clayton.
(1995). Whole-Genome Random
Sequencing and Assembly of Haemophilus
influenzae Rd. Science. 269: 496-512.
1323
4. Chambers, H. F. (1999) Penicillin-binding
protein-mediated resistance in
pneumococci and staphylococci. The
Journal of Infectious Diseases. 179: S353-
S359.
5. Venkatesan, S. K., Shukla, A. K. and
Dubey, V. K. (2010). Molecular docking
studies of selected tricyclic and quinine
derivatives on trypanothione reductase of
Leishmania infantum. J. Comp. Chem. 31
(13):2463-2474.
6. Saravanan, P., Venkatesan, S. K., Mohan,
C. G., Patra, S. and Dubey V. K. (2010)
Mitogen-activated protein kinase 4 of
Leishmania parasite as a therapeutic target.
Eur. J. Med. Chem. 45, 5662-5670.
7. Jean van Heijenoort. (2007). Lipid
Intermediates in the Biosynthesis of
Bacterial Peptidoglycan. Microbiol Mol
Biol Rev. 71(4): 620–635.
8. Adeline Derouaux, Benoît Wolf, Claudine
Fraipont, Eefjan Breukink, Martine
Nguyen-Distèche and Mohammed Terrak.
(2008). The Monofunctional
Glycosyltransferase of Escherichia coli
Localizes to the Cell Division Site and
Interacts with Penicillin-Binding Protein.
J Bacteriol. 190(5): 1831–1834.
9. Shide Liang, Samy O. Meroueh, Guangce
Wang, Chao Qiu and Yaoqi Zhou. (2010).
Consensus scoring for enriching nearnative
structures from protein-protein
docking decoys. Proteins. 1; 75(2): 397–
403.
10. Pamela J. Yeh, Matthew J. Hegreness,
Aviva Presser Aiden and Roy Kishony.
(2009). Drug interactions and the evolution
of antibiotic resistance. Nature Reviews
Microbiology 7: 460-466.
Ramya Jyothi et al