Index 389 transplant, effect of clonal abnormalities, see clones, cytogenetic clonal abnormalities transplant, graft-versus-host disease (GvHD), 193, 216, 218, 348; chronic cutaneous, 230; chronic intestinal, 92; concurrent medication, effect on, 204; immune recovery affected by, 229; infection risk, 216, 218; management of, 192-193, 213-215; mortality from, 180, 214; ocular complications, see vision; prevention therapy side effects, 214; prophylaxis, 67, 179-181, 192-193, 211-215, 223-224; risk of, 182-183, 187, 190, 193; risk of carcinoma from, 57, 92, 192, 217, 229 transplant, grafts, 189-192; engraftment, 189, 192-193; graft failure, prophylaxis and treatment, 180-182, 192-193, 211, 216-218 transplants, immunizations post-transplant, see vaccinations, immunizations transplant, immunosuppression and immune reconstitution, 211, 214-216, 229, 233, 353 transplant, late effects, 191, 193-194, 200, 216-17, 223-235; endocrine, 159, 194, 227; etiology of, 225; growth and development, 227; hematology, 226; immunology, 229; iron overload, 226, see also iron overload; malignancy risk, 229-230; metabolic syndrome, 228, see also metabolic syndrome; ocular complications, 230, see also vision; quality of life, 231 transplant, matched sibling donor, 178-196; androgen and cytokine therapy prior to transplant, 186-187; cytoreductive regimens, TBI and non-TBI, 180-182, 190-191; indications for transplant, 183-186; overview and results of transplants, 178-179; post-transplant evaluation and complications of, 193-194; pretransplant evaluation, patient and donor, 188-189; selection of donor, 187-188; source of stem cell graft, 189-190; timing of transplant, 62-65, 183 transplant, organ function, effect on transplant, 68, 183, 186, 193- 194, 198-199, 209, 228 transplant, post-transplant: long-term follow-up, 224-233; quality of life, 231, see also quality of life transplant, radiation, effect on fertility, 127; risk factor for cancer, 217; sensitivity of FA patients to, 178; TBI cytoreductive regimen, unrelated donor, 211-212; TBI, side effects of, 212; TBIbased cytoreductive regimen, matched related donor, 180, 190, 368; thoraco-abdominal irradiation (TAI), 190; preparative regimen without radiation, 181, 190-191; preparative therapy side effects, 212
390 <strong>Fanconi</strong> <strong>Anemia</strong>: Guidelines for Diagnosis and Management transplant, selection of transplant center, 51, 62, 182-183, 186, 197, 199-201 transplant, stem cell source, marrow, 189, 191-192, 198-199, 208- 209; peripheral blood, 189-190, 208-209, 361; umbilical cord blood, 189, 192, 194, 198-199, 205-209, 287, 369 transplant, transfusions prior to, see transfusions transplant, unrelated donor, 197-222; alternatives to, 219; collection of autologous stem cells, 217; donor search, insurance company approval, 206; donor search, selection, and timing of process, 63-64, 204-209; eligibility for transplant, 200, 210; exclusion criteria for, 209; indications for, 62-65, 198-201; infection post-transplant, 218-219; infectious disease prophylaxis, 215-216; initial assessment at transplant center, 201-204; overview, risk factors, and results of, 197-199 transplant-related mortality and survival, 57, 63, 179-181, 183, 197-199, 214, 217, 219-220, 229, 251; peritransplant mortality, 183 transposons, 237 tumor, see cancer or specific type of cancer ulna, dysplastic, 109-110; in centralization, 112-115; lengthening of, 116 underweight, appetite stimulants, 85-87; assessment of growth, 82-83; delayed gastric emptying, effect on, 81; duodenal atresia or stenosis correction, effect on, 78-79; malabsorption, effect on, 80, 83, 92, 140, 213; medical causes of, 79-81, 137- 140; nutrition, see nutrition; nutritional causes of, 137, 139- 140; poor oral intake, 79-82; supplemental nutrition for, 82-85 urinary tract, congenital anomalies, 225; glucose in urine, 140; hemorrhagic cystitis, 182, 212, 218; ureteral reflux, 203; urine methylmalonic acid levels, 49 uterus, 35, 121, 154, 336, 369; uterine or menstrual bleeding, 123- 124 vaccinations, immunizations, 203; hepatitis A and B, 91; HPV, 123, 126, 131, 229-230, 233, 254, 267; post-transplant, 229, 233; influenza, 229 VACTERL, VACTERL-H, 38, 46, 77 vaginal, dryness, vaginitis, strictures, 213 virus, viral, see infections vision, 34; astigmatism, 35; cataracts, 35, 212, 218, 230; ischemia microvascular retinopathy, 230; keratoconjunctivitis sicca syndrome, 213, 230, 354; ocular complications post-transplant, 213, 225, 230; photophobia, 213, 362; strabismus, 35; vision
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