guidebook. - Fanconi Anemia Research Fund

36
Fanconi Anemia: Guidelines for Diagnosis and Management
absolutely imperative to test for FA if a stem cell transplant
is planned.
Table 1: Cancer in Patients with FA, Not Transplanted,
1927-2007*
Median Age
in FA
(Range)
Median
Age for
Sporadic
Cancers
Type of Cancer Male Female
Not
Stated Total
Leukemia:
Acute myeloid 68 59 12 139 13 (0.1-50) 67
leukemia (AML)
Acute leukemia, 3 9 0 12 14 (9-24)
unspecified
Acute lymphoid 3 3 0 6 5 (1-10) 13
leukemia (ALL)
0 3 1 4 16 (11, 20) NA
Chronic
myelomonocytic
leukemia (CMML)
Solid Tumors:
Head and neck 15 21 0 36 27 (13-46) 62
Esophagus 3 9 0 12 27 (20-50) 69
Vulva - 17 - 17 26 (14-38) 68
Cervix - 6 - 6 24 (22, 25) 48
Breast 0 7 0 7 37 (26-45) 61
Brain 8 11 4 23 3 (0.5-11) 10
Renal Wilms 9 4 3 16 1(0.5-5) 5
Renal carcinoma 0 1 0 1 36 65
Neuroblastoma 4 1 2 7 0.7 (0.2-1.4) 0.5
Lung 3 0 0 3 29 (23-34) 70
Stomach 2 0 1 3 28 (21, 35) 71
Lymphoma 1 1 0 2 1.4 (0.3, 2.5) 67
Colon 0 1 0 1 21 71
Retinoblastoma 0 1 0 1 0.3 0.5
Osteosarcoma 0 1 0 1 7 15
Bladder 1 0 0 1 38 73
Dermatofibroma 0 1 0 1 20 56
Liver Tumors:
Adenoma 7 8 0 15 11 (8-48) NA
Carcinoma 18 10 0 28 14 (5-50) 65
*Data from 1,865 literature cases. 161 patients with leukemia; 11
also had a solid tumor. 181 solid tumors in 166 patients. Twentythree
had 2-4 solid tumors. A hyphen (-) indicates that the cancer
type is not possible in males. Ages are in years. If the number
of ages is fewer than the number of patients, some data missing.
NA=not available. † Median ages for sporadic cancers in pediatric
patients where available. Ages for sporadic cancers from SEER.
(Alter, unpublished)