guidebook. - Fanconi Anemia Research Fund

Glossary
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whether dose adjustment is necessary, and as a measure
for the required intensity of palliative care. It is also
used in cancer randomized controlled trials as a measure
of quality of life. Children, who might have more
trouble expressing their experienced quality of life, are
evaluated according to the Lansky status criteria, using
a somewhat more observational scoring system, such as
“fully active, normal” to “doesn’t play, does not get out
of bed” to “unresponsive.” 19
Larynx: The upper part of the respiratory passage that
is bounded above by the glottis, is continuous below
with the trachea, has a complex cartilaginous or bony
skeleton capable of limited motion through the action of
associated muscles, and has a set of elastic vocal cords
that play a major role in sound production and speech;
also called “voice box.” 1
Leukemia: Leukemia is a group of bone marrow
diseases involving an uncontrolled increase in white
blood cells (leukocytes). The leukemia most commonly
acquired by FA patients is acute myelogenous leukemia.
5
Leukocytes: White blood cells. 2
Leukopenia: Low white cell count. 2
Leukoplakia: A condition commonly considered precancerous
in which thickened white patches of epithelium
occur on the mucous membranes especially of the
mouth, vulva, and renal pelvis. 1
Lichen planus: A condition of the genitals, skin or
mouth that results in an itchy, swollen rash on the
genitals (typically on the vulva); tender, painful, bluishwhite
lesions in the mouth; and/or shiny, scaly, flattopped,
purplish-pink bumps on the skin.