guidebook. - Fanconi Anemia Research Fund

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Fanconi Anemia: Guidelines for Diagnosis and Management
deficiency of the sex hormones (estrogen and testosterone)
and halts normal sexual maturation. 5
Graft-versus-host disease (GvHD): A complication of
bone marrow transplantation which occurs when donor
T-cells attack the patient’s cells. GvHD is more likely
to occur when there is HLA mismatching. GvHD is
classified in stages from Grade I (minor) to Grade IV
(extremely serious). 2
Granulocyte: Type of white blood cell. It is also called
neutrophil or polymorphonuclear leukocyte (poly),
which is the infection-fighting cell.
Gynecomastia: The development of large breasts in
males. Gynecomastia during puberty is not uncommon
and usually goes away over a period of months. 5
H2-antagonists: Medicines that help decrease stomach
acid. 5
Hematocrit: Ratio of red blood cells to plasma in the
blood; portion of the blood’s total volume that is made
up of red blood cells. 2
Hematopoiesis: The formation and development of
blood cells. 2
Hematopoietic growth factors: See Colony stimulating
factors.
Hemochromatosis (aka iron overload): Occurs when
too much iron builds up in the liver. This leads to liver
enlargement. In Fanconi anemia, this is usually caused
from ineffective blood production, abnormal iron
absorption, or receiving a large number of blood transfusions,
which boost iron levels.
Hemodynamic: Relating to or functioning in the
mechanics of blood circulation. 1