18.01.2015 Views

guidebook. - Fanconi Anemia Research Fund

guidebook. - Fanconi Anemia Research Fund

guidebook. - Fanconi Anemia Research Fund

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

262<br />

<strong>Fanconi</strong> <strong>Anemia</strong>: Guidelines for Diagnosis and Management<br />

and morbidity of head and neck cancer in this patient<br />

population. Early and frequent head and neck examinations,<br />

including careful oral cavity evaluations and flexible<br />

fiberoptic laryngoscopy are important surveillance<br />

measures. Appropriate surgical resection remains the<br />

mainstay of treatment for FA patients, since radiation<br />

and chemotherapy are poorly tolerated. If radiation and<br />

chemotherapy are required for advanced tumors, they<br />

should be used with caution and by physicians who<br />

have experience in identifying, preventing, and treating<br />

associated complications.<br />

References<br />

1. Alter BP, Greene MH, Velazquez I, Rosenberg PS. Cancer in<br />

<strong>Fanconi</strong> anemia. Blood 2003; 101(5): 2072-2073.<br />

2. Kutler DI, Auerbach AD, Satagopan JH, et al. High incidence<br />

of head and neck squamous cell carcinoma in patients with <strong>Fanconi</strong><br />

anemia. Archives of Otolaryngology-Head & Neck Surgery<br />

2003; 192(1): 106-112.<br />

3. Ries, LAG, Melbert D, Krapcho M, et al. (eds). SEER Cancer<br />

Statistics Review, 1975-2005, National Cancer Institute, Bethesda,<br />

MD, http://seer.cancer.gov/csr/1975_2005/, based on November<br />

2007 SEER data submission, posted to the SEER web site, 2008.<br />

4. Maier H, Sennewald E, Heller GFWD, Weidauer H. Chronic<br />

alcohol consumption-the key risk factor for pharyngeal cancer.<br />

Archives of Otolaryngology-Head and Neck Surgery 1994; 110(2):<br />

168-173.<br />

5. Blot WJ, Mclaughlin JK, Winn DM, et al. Smoking and drinking<br />

in relation to oral and pharyngeal cancer. Cancer <strong>Research</strong><br />

1988; 48(11): 3282-3287.<br />

6. Sanghvi LD, Rao DN, Joshi S. Epidemiology of head and neck<br />

cancers. Seminars in Surgical Oncology 1989; 5(5): 305-309.

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!