guidebook. - Fanconi Anemia Research Fund

Chapter 6: Gynecologic and Fertility Issues in Female FA Patients
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Future Research Directions
1. Defining osteoporosis risk in FA women.
2. Defining the risk of congenital reproductive tract
anomalies in FA women.
3. Fertility preservation for patients undergoing stem
celltransplantation.
4. The safety and immunogenicity of HPV vaccination
in FA men and women.
5. Improving diagnosis and treatment of genital tract
dysplasias before cancer arises.
References
1. Faivre L, Portnoi MF, Pals G, et al. Should chromosome breakage
studies be performed in patients with VACTERL association
American Journal of Medical Genetics 2005; 137(1): 55-58.
2. Oppelt P, von Have M, Paulsen M, et al. Female genital malformations
and their associated abnormalities. Fertility and Sterility
2007; 87(2): 335-342.
3. Giri N, Batista DL, Alter BP, Stratakis CA. Endocrine abnormalities
in patients with Fanconi anemia. Journal of Clinical
Endocrinology and Metabolism 2007; 92(7): 2624-2631.
4. Koomen M, Cheng NC, van de Vrugt HJ, et al. Reduced fertility
and hypersensitivity to mitomycin C characterize Fancg/Xrcc9
null mice. Human Molecular Genetics 2002; 11(3): 273-281.
5. Genazzani AD, Ricchieri F, Lanzoni C, Strucchi C, Jasonni
VM. Diagnostic and therapeutic approach to hypothalamic amenorrhea.
Annals of the New York Academy of Sciences 2006; 1092:
103-113.
6. Hoffman B, Bradshaw KD. Delayed puberty and amenorrhea.
Seminars in Reproductive Medicine 2003; 21(4): 353-362.
7. Garland SM, Hernandez-Avila M, Wheeler CM, et al. Quadrivalent
vaccine against human papillomavirus to prevent anogenital
diseases. New England Journal of Medicine 2007; 356(19): 1928-
1943.