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Continued from page 44 – HIV Drug causes Liver Damage<br />

blood to back up into the esophagus. Veins in the throat<br />

can be<strong>com</strong>e so enlarged that they rupture, leading to<br />

serious and potentially fatal bleeding.<br />

Although the FDA stated that the benefits for HIV<br />

patients still outweigh the risks, it warned that Videx<br />

patients should be closely monitored for any signs of<br />

portal hypertension. Furthermore, it noted that "the<br />

decision to use this drug ... must be made on an<br />

individual basis between the treating physician and the<br />

patient."<br />

Videx was first approved in 1991, and the delayed<br />

release version was approved in 2000. The drug is a type<br />

of antiretroviral drug known as a nucleoside analogue,<br />

and slows the proliferation of HIV to prolong the onset<br />

of AIDS and extend the life of patients. It has previously<br />

been linked to other forms of liver damage, especially in<br />

<strong>com</strong>bination with other antiretroviral drugs including<br />

hydroxyurea and ribavirin.<br />

According to a spokesperson for manufacturer Bristol-<br />

Myers Squib, worldwide sales of the drug amounted to<br />

$71 million in 2009.<br />

http://www.naturalnews.<strong>com</strong>/z029225_liver_damage_drugs.ht<br />

ml<br />

☻☻☻☻☻☻<br />

Hormonal Contraception Ups<br />

HIV Risk in Women<br />

October 3, 2011<br />

Hormonal contraception may make it easier for HIV to<br />

spread between heterosexual sex partners, according to a<br />

new study conducted in Africa. Women in the study who<br />

used hormonal contraception had double the risk of<br />

acquiring HIV or transmitting it to their male partners as<br />

those who did not use hormonal contraception.<br />

While hormonal conception includes both oral<br />

contraception and injectable forms of birth control, the<br />

findings were most pronounced for women using<br />

injectables, like Depo-Provera, the study said. "These<br />

findings have important implications for family planning<br />

and HIV-1 prevention programs, especially in settings<br />

with high HIV-1 prevalence", said study researcher<br />

Jared Baeten, of the University of Washington. HIV-1 is<br />

the prevalent subtype of HIV. "Re<strong>com</strong>mendations<br />

regarding contraceptive use, particularly emphasizing<br />

the importance of dual protection with condoms and the<br />

use of non-hormonal and low-dose hormonal methods<br />

for women with or at risk for HIV-1, are urgently needed",<br />

said study researcher Renee Heffron, also of the<br />

University of Washington.<br />

HIV and contraception<br />

More than 140 million women worldwide use hormonal<br />

contraception, such as daily oral pills and long-acting<br />

injectables, the study said. A large proportion of the 16<br />

million women living with HIV in sub-Saharan Africa<br />

also use hormonal contraception. The new study included<br />

3,790 heterosexual couples in which one partner was HIV<br />

positive and the other was not. The couples were from<br />

seven <strong>African</strong> countries (Botswana, Kenya, Rwanda,<br />

South Africa, Tanzania, Uganda and Zimbabwe).<br />

Women using hormonal contraceptives were twice as<br />

likely to be<strong>com</strong>e infected with HIV. The risk was<br />

increased among those using injectable and oral<br />

contraceptives, although for the increase seen in those<br />

using oral contraceptives was smaller and may have been<br />

due to chance. Additionally, women who were HIVpositive<br />

at the beginning of the study and using injectable<br />

contraception were twice as likely to transmit the virus to<br />

their male partner as women who did not use hormonal<br />

contraception. The results held even after researchers<br />

took into account factors that could affect the HIV<br />

transmission rate, such as the whether the woman was<br />

pregnant, and whether condoms were used. It's possible<br />

hormonal contraception causes biological changes, such<br />

as changes to the cells that line the vagina or cervix, that<br />

influence susceptibility to HIV, the researchers said.<br />

What's to be done<br />

"Active promotion of [injectable contraceptives] in areas<br />

with high HIV incidence could be contributing to the<br />

HIV epidemic in sub-Saharan Africa, which would be<br />

tragic," Charles Morrison from <strong>Clinic</strong>al Sciences,<br />

Durham, North Carolina, said in an ac<strong>com</strong>panying<br />

editorial. "Conversely, limiting one of the most highly<br />

used effective methods of contraception in sub-Saharan<br />

Africa would probably contribute to increased maternal<br />

mortality and morbidity and more low birth weight babies<br />

and orphans — an equally tragic result," Morrison said.<br />

Morrison also noted the study was not originally designed<br />

to measure the effect of hormonal contraception on HIV<br />

risk, and that the number of women using these<br />

contraceptives was small. In addition, it was <strong>com</strong>mon for<br />

women in the study to switch their contraception method,<br />

from hormonal to non-hormonal contraception, such as<br />

intrauterine devices. It's time to find a definitive answer<br />

to the question of whether hormonal contraception<br />

increases HIV acquisition risk, Morrison said. This can<br />

be done through a trial in which participants are<br />

randomly assigned to receive hormonal contraception or<br />

not.<br />

http://www.msnbc.msn.<strong>com</strong>/id/44765548/ns/healthwomens_health/#.ToqdOHLT4i0<br />

☻☻☻☻☻☻<br />

-45- <strong>Traditional</strong> <strong>African</strong> <strong>Clinic</strong> October 2011

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