abstract book topim2 - European Society for Molecular Imaging (ESMI)
abstract book topim2 - European Society for Molecular Imaging (ESMI)
abstract book topim2 - European Society for Molecular Imaging (ESMI)
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DUAL AND INNOVATIVE IMAGING MODALITIES<br />
ULTRA RESOLUTION SPECT COMBINED WITH OTHER MODALITIES<br />
Freek J. Beekman 1,2,3 , F. van der Have 2,3 B. Vastenhouw 2,3 , W. J. Branderhorst 2 , R.<br />
Ramakers 2 , C. Ji 2<br />
1 Delft University of Technology, Delft, The Netherlands<br />
2 University Medical Centre Utrecht, Utrecht, The Netherlands<br />
3 MILabs, Utrecht, The Netherlands<br />
f.j.beekman@tudelft.nl<br />
Aim: To develop an extremely user friendly and reliable SPECT system with<br />
unsurpassed resolution that can be readily combined with other imaging modalities.<br />
Methods: We constructed a new rodent SPECT system (U-SPECT-II [1]) and a CT<br />
scanner (U-CT) with dedicated multi-modal animal beds and registration software <strong>for</strong><br />
localized sub–half-millimeter total-body SPECT. Three optical cameras and a<br />
dedicated interface are fully integrated with U-SPECT to allow pre-selection of the<br />
field-of-view without adding any dose to the animal. This facilitates focusing the<br />
pinholes, thereby maximizing sensitivity <strong>for</strong> the task at hand. Furthermore, the optical<br />
cameras allow <strong>for</strong> unique registration possibilities, in particular with images from<br />
independent optical modalities.<br />
Results: SPECT resolutions better than 0.35mm where obtained <strong>for</strong> Tc-99m.<br />
Resolutions with In-111 and I-125 were barely degraded, compared to Tc-99m.<br />
Image registration of SPECT with CT was better than 0.2 mm.<br />
Discussion: U-SPECT-II and combined U-SPECT-II/U-CT can be used <strong>for</strong> novel<br />
applications in the study of dynamic biologic systems and pharmaceuticals at the<br />
suborgan level. Discrimination of molecule concentrations between adjacent volumes<br />
of about 0.04 µL in mice and 0.5 µL in rats with U-SPECT-II is readily possible.<br />
Accurate anatomical localization can be done efficiently and cost-effectively with<br />
independent modalities such as CT or MRI. For imaging small animals separate<br />
systems offer unique advantages over integrated devices [2].<br />
References:<br />
[1] F. van der Have et al. U-SPECT-II: An Ultra-High-Resolution Device <strong>for</strong> <strong>Molecular</strong><br />
Small-Animal <strong>Imaging</strong>, J. Nucl. Med. 2009<br />
[2] F.J. Beekman and B.F. Hutton “Multi-modality imaging on track”, Eur. J. Nucl.<br />
Med. Mol. Im, 2007<br />
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