CST Guide:
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Section I: Research Areas<br />
chapter 01: GENE EXPRESSION, EPIGENETICS, AND NUCLEAR FUNCTION<br />
These protein targets represent key<br />
nodes within chromatin/epigenetic<br />
regulation signaling pathways and<br />
are commonly studied in chromatin/<br />
epigenetic regulation research. Primary<br />
antibodies, antibody conjugates, and<br />
antibody sampler kits containing these<br />
targets are available from <strong>CST</strong>.<br />
Listing as of September 2014. See our<br />
website for current product information.<br />
M Monoclonal Antibody<br />
P Polyclonal Antibody<br />
E PathScan ® ELISA Kits<br />
S SignalSilence ® siRNA<br />
C Antibody Conjugate<br />
Commonly Studied Chromatin/Epigenetic Regulation Targets<br />
Target M P E S C<br />
ACF1<br />
•<br />
ARID1A/BAF250A<br />
• •<br />
ASF1A<br />
•<br />
ASF1B<br />
• •<br />
ASH2L<br />
•<br />
Bmi1 • • •<br />
BORIS<br />
•<br />
BTAF1<br />
•<br />
Brd2<br />
•<br />
BRD4<br />
•<br />
Brg1<br />
•<br />
BRM<br />
• •<br />
CABIN1<br />
•<br />
CBP<br />
•<br />
Acetyl-CBP (Lys1535)/p300 (Lys1499) •<br />
CDK7<br />
• •<br />
CDK8<br />
•<br />
CDK9<br />
•<br />
Phospho-CDK9 (Thr186) •<br />
CDK12<br />
•<br />
CENP-A<br />
• •<br />
Phospho-CENPA (Ser7) •<br />
CHAF1A<br />
•<br />
CHD1 • •<br />
CHD1L<br />
•<br />
CHD2<br />
•<br />
CHD3<br />
•<br />
CHD4<br />
• •<br />
CHD7<br />
•<br />
CHD8<br />
• •<br />
CLOCK<br />
•<br />
CTCF • • •<br />
CTDSPL2<br />
•<br />
Phospho-CTDSPL2 (Ser104) •<br />
CTR9<br />
•<br />
CXXC1<br />
•<br />
Cyclin T1<br />
•<br />
DBC1<br />
• •<br />
Phospho-DBC1 (Thr454) •<br />
DMAP1<br />
•<br />
DNMT1<br />
•<br />
DNMT3A<br />
• •<br />
DNMT3L<br />
•<br />
DR1<br />
•<br />
ELP1/IKBKAP<br />
•<br />
ELP3<br />
•<br />
ESET<br />
•<br />
EWS • •<br />
Ezh2<br />
• • • • •<br />
G9a/EHMT2<br />
•<br />
GCN5L2<br />
•<br />
Histone H2A<br />
• •<br />
Acetyl-Histone H2A (pan)<br />
•<br />
Acetyl-Histone H2A (Lys5) •<br />
Ubiquityl-Histone H2A (Lys119) •<br />
MacroH2A1<br />
• •<br />
MacroH2A1.2<br />
•<br />
Histone H2A.X<br />
• •<br />
Target M P E S C<br />
Phospho-Histone H2A.X (Ser139) • • •<br />
•<br />
Phospho-Histone H2A.X (Ser139/<br />
Tyr142)<br />
Histone H2A.Z<br />
•<br />
Histone H2B • • • •<br />
Acetyl-Histone H2B (Lys5) • •<br />
Acetyl-Histone H2B (Lys12) • •<br />
Acetyl-Histone H2B (Lys15) •<br />
Acetyl-Histone H2B (Lys20) • •<br />
Phospho-Histone H2B (Ser14) •<br />
Ubiquityl-Histone H2B (Lys120) •<br />
Histone H3 • • • •<br />
Acetylated Histone H3 (pan) •<br />
Acetyl-Histone H3 (Lys9) • • •<br />
•<br />
Acetyl- and Phospho-Histone H3<br />
(Lys9/Ser10)<br />
Acetyl-Histone H3 (Lys14) •<br />
Acetyl-Histone H3 (Lys18) • • •<br />
Acetyl-Histone H3 (Lys27) • •<br />
Acetyl-Histone H3 (Lys36) •<br />
Acetyl-Histone H3 (Lys56) •<br />
Methyl-Histone H3 (Arg2) •<br />
Mono-Methyl-Histone H3 (Lys4) • • •<br />
Di-Methyl-Histone H3 (Lys4) • •<br />
Tri-Methyl-Histone H3 (Lys4) • • • •<br />
•<br />
Symmetric Di-Methyl-Histone H3<br />
(Arg8)<br />
Pan-Methyl-Histone H3 (Lys9) • •<br />
Di-Methyl-Histone H3 (Lys9) • • •<br />
Di/Tri-Methyl-Histone H3 (Lys9) •<br />
Tri-Methyl-Histone H3 (Lys9) •<br />
Di-Methyl-Histone H3 (Lys27) • •<br />
Tri-Methyl-Histone H3 (Lys27) • • •<br />
Di-Methyl-Histone H3 (Lys36) • •<br />
Tri-Methyl-Histone H3 (Lys36) • •<br />
Mono-Methyl-Histone H3 (Lys79) • •<br />
Di-Methyl-Histone H3 (Lys79) •<br />
Tri-Methyl-Histone H3 (Lys79) •<br />
Cleaved Histone H3 (Thr22) • •<br />
Phospho-Histone H3 (Thr3) • •<br />
Phospho-Histone H3 (Ser10) • • • •<br />
Phospho-Histone H3 (Thr11) • •<br />
Phospho-Histone H3 (Ser28) •<br />
Histone H4 • • •<br />
Acetyl-Histone H4 (pan)<br />
•<br />
Acetyl-Histone H4 (Lys5) • •<br />
Acetyl-Histone H4 (Lys8) • •<br />
Acetyl-Histone H4 (Lys12) • • •<br />
Acetyl-Histone H4 (Lys16) • •<br />
Mono-Methyl-Histone H4 (Lys20) •<br />
Di-Methyl-Histone H4 (Lys20) •<br />
Tri-Methyl-Histone H4 (Lys20) •<br />
HDAC1<br />
• •<br />
HDAC2<br />
• •<br />
HDAC3<br />
• •<br />
Phospho-HDAC3 (Ser424) •<br />
HDAC4 • • •<br />
•<br />
Phospho-HDAC4 (Ser246)/HDAC5<br />
(Ser259)/HDAC7 (Ser155)<br />
Target M P E S C<br />
Phospho-HDAC4 (Ser632)/HDAC5<br />
(Ser661)/HDAC7 (Ser486) •<br />
HDAC6<br />
•<br />
HELLS<br />
•<br />
HEXIM1<br />
• •<br />
HIRA<br />
•<br />
HMGA1<br />
•<br />
HMGA2<br />
• •<br />
HMGB1<br />
• •<br />
HMGB2<br />
•<br />
HMGN1<br />
• •<br />
HMGN2<br />
•<br />
HP1α<br />
•<br />
HP1α/β<br />
•<br />
HP1β<br />
• •<br />
HP1γ<br />
•<br />
Phospho-HP1γ (Ser83) •<br />
INTS9<br />
•<br />
JARID1A<br />
•<br />
JARID1B<br />
•<br />
JARID1C<br />
•<br />
JARID2<br />
•<br />
JMJD1B/JHDM2B<br />
•<br />
JMJD1B<br />
•<br />
JMJD2A<br />
•<br />
JMJD2B • • •<br />
JMJD3<br />
•<br />
LCMT1<br />
•<br />
LEDGF<br />
•<br />
LSD1<br />
• •<br />
MBD3<br />
•<br />
MeCP2<br />
•<br />
MED12<br />
•<br />
MED23<br />
•<br />
MED26<br />
•<br />
Menin<br />
•<br />
MEP50<br />
• •<br />
MLLT1/ENL<br />
•<br />
MORF4L1/MRG15 • •<br />
MTA1<br />
•<br />
NCoR1<br />
•<br />
NFI-C<br />
•<br />
Nucleomethylin<br />
•<br />
NRF2<br />
•<br />
Nucleolin<br />
•<br />
NUT1<br />
•<br />
PAF1<br />
•<br />
PCAF<br />
•<br />
PHC1<br />
•<br />
PHF2<br />
•<br />
PHF20<br />
•<br />
POLR3A<br />
•<br />
Pontin/RUVBL1<br />
•<br />
PRMT1<br />
•<br />
PRMT4/CARM1<br />
• •<br />
PRMT5/Skb1Hs Methyltransferase •<br />
RAD21<br />
•<br />
RBAP46/RBAP48<br />
• •<br />
RBBP5<br />
• •<br />
RBAP46<br />
•<br />
Target M P E S C<br />
Reptin/RuvBL2<br />
• •<br />
Ring1A<br />
• •<br />
RING1B<br />
•<br />
RNF20<br />
•<br />
RNF40<br />
• •<br />
Rpb1 CTD<br />
•<br />
Phospho-Rpb1 CTD (Ser2) •<br />
Phospho-Rpb1 CTD (Ser2/Ser5) •<br />
Phospho-Rpb1 CTD (Ser5) • •<br />
Phospho-Rpb1 CTD (Ser7) •<br />
SATB1<br />
• •<br />
Phospho-SATB1 (Ser47) •<br />
SET7/SET9<br />
• •<br />
SET8<br />
•<br />
SIN3A<br />
•<br />
SirT1 • • •<br />
Phospho-SirT1 (Ser27) •<br />
Phospho-SirT1 (Ser47) •<br />
SirT2<br />
•<br />
SirT3<br />
•<br />
SirT5<br />
•<br />
SirT6 • • •<br />
SirT7<br />
•<br />
SMARCA1<br />
• •<br />
SMARCAD1<br />
•<br />
SMARCC1/BAF155 • •<br />
SMARCC2/BAF170 • •<br />
SMYD2<br />
• •<br />
SMYD3<br />
•<br />
SNF2H<br />
•<br />
SNF5<br />
•<br />
SP1 • • •<br />
SPT5<br />
•<br />
SPT16<br />
•<br />
SRC-1<br />
•<br />
SRC-3<br />
•<br />
Phospho-SRC-3 (Thr24) •<br />
SSRP1<br />
• •<br />
SSU72<br />
•<br />
SUV39H1<br />
•<br />
SUZ12<br />
•<br />
TAF1<br />
•<br />
TAF15<br />
•<br />
TBP<br />
• •<br />
TCEB3/Elongin A<br />
•<br />
TFII-I<br />
•<br />
TFIIB<br />
•<br />
TFIIFα<br />
•<br />
TH1L<br />
• •<br />
Tip60<br />
•<br />
Topoisomerase IIα<br />
• •<br />
Phospho-Topoisomerase IIα (Ser1469) •<br />
TRIM29/ATDC<br />
•<br />
TRRAP<br />
•<br />
UHRF1<br />
•<br />
WDR5<br />
•<br />
WSTF<br />
•<br />
XPB<br />
•<br />
XPD<br />
•<br />
YY1<br />
•<br />
155<br />
2012–2014 citations<br />
<strong>CST</strong> antibodies for Histone H3 have<br />
been cited over 155 times in highimpact,<br />
peer-reviewed publications<br />
from the global research community.<br />
Select Citations:<br />
Crotti, A. et al. (2014) Mutant<br />
Huntingtin promotes autonomous<br />
microglia activation via myeloid<br />
lineage-determining factors. Nat.<br />
Neurosci. 17, 513−521.<br />
Tanaka-Nakanishi, A. et al. (2014)<br />
HTLV-1 bZIP factor suppresses<br />
apoptosis by attenuating the function<br />
of FoxO3a and altering its localization.<br />
Cancer Res. 74, 188−200.<br />
Hast, B.E. et al. (2014) Cancerderived<br />
mutations in KEAP1 impair<br />
NRF2 degradation but not ubiquitination.<br />
Cancer Res. 74, 808−817.<br />
Chen, C.H. et al. (2014) Synergistic<br />
interaction between the HDAC inhibitor,<br />
MPT0E028, and sorafenib in liver<br />
cancer cells in vitro and in vivo. Clin.<br />
Cancer Res. 20, 1274−1287.<br />
Ghare, S.S. et al. (2014) Coordinated<br />
Histone H3 Methylation and Acetylation<br />
Regulate Physiologic and Pathologic<br />
Fas Ligand Gene Expression in<br />
Human CD4+ T Cells. J. Immunol.<br />
193, 412−421.<br />
Karijolich, J. et al. (2014) Coordinated<br />
Histone H3 Methylation and<br />
Acetylation Regulate Physiologic and<br />
Pathologic Fas Ligand Gene Expression<br />
in Human CD4+ T Cells. J. Virol.<br />
88, 7024−7035.<br />
Galli, G.G. et al. (2014) Prdm5<br />
suppresses Apc(Min)-driven intestinal<br />
adenomas and regulates monoacylglycerol<br />
lipase expression. Oncogene<br />
33, 3342−3350.<br />
Khalaj, M. et al. (2014) A missense<br />
mutation in Rev7 disrupts formation of<br />
Polzeta, impairing mouse development<br />
and repair of genotoxic agent-induced<br />
DNA lesions. J. Biol. Chem. 289,<br />
3811−3824.<br />
Belozerov, V.E. et al. (2014) In vivo<br />
interaction proteomics reveal a novel<br />
p38 mitogen-activated protein kinase/<br />
Rack1 pathway regulating proteostasis<br />
in Drosophila muscle. Mol. Cell Biol.<br />
34, 474−484.<br />
Gray, C.M. et al. (2014) Noncanonical<br />
NF-kappaB signaling is limited by<br />
classical NF-kappaB activity. Sci.<br />
Signal. 7, 13.<br />
24 For Research Use Only. Not For Use in Diagnostic Procedures. See pages 302 & 303 for Pathway Diagrams, Application, and Reactivity keys.<br />
www.cellsignal.com/cstchromatin 25
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