Lung function measurements in children - copsac

More documents

Recommendations

Info

Acknowledgements The thesis was written during my employment at the Department of Pediatrics, Næstved Hospital and the Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte from 2005 to 2008. The work is a product of joint efforts. First of all, I would like to thank my supervisor, Professor Hans Bisgaard, for his enormous inspiration, help and support. Thank you for the gentle pushes to the edge, challenging me, and not least thank you for trusting and believing in me. Also I would thank Dr. Carsten Vrang and Headnurse Kirsten Holgersen for never-ending support and understanding, you make every problem possible to solve and also thanks to my colleagues at Næstved Hospital. To all my dear colleagues at the COPSAC cohort (Malene Stage, Lene Toft-Jensen, Klaus Bønnelykke, Martin Brasholt, Bo Chawes, Liselotte B. Halkjær, Mette Hermansen, Lotte Loland, Nadja H. Vissing, Kirsten H. Mathiesen, Lotte Klansø, Lena Vind, Pia F. Jensen, Eskil Kreiner-Møller, Christian B. Pipper, Sannie V. Thorsen, Signe M. Jensen, Florent Baty and Richard Flaaten: I wish to thank each and one of you with all my heart for the practical help, scientific feedback and laughs. It would not have been the same without you. A warm thank to all the doctors and staff at the different hospitals: Næstved (Hanne Andreassen, Ann Katrine H. Thomsen), Skejby (Lena Johnsen, Hanne Niekrenz, Ellen Margrethe Raaby, Jørn M. Henriksen, Oluf Schiøtz), Kolding (Birgitte Christensen, Tove Duus, Signe Vahlkvist, Søren Pedersen), Hvidovre (Bent Klug) and Rigshospitalet (Birgitte Hanel, Kim G. Nielsen). I could not have done the multicenter trial without you and I am most grateful for your efforts. I am also grateful to have worked with my competent and skilful co-authors (Simon F. Thomsen, Lone G. Stensballe, Kirsten O. Kyvik, Axel Skytthe), who have given me valuable advice and helped me through the papers. A warm thank to my dear friend Dr. Lise Aksglæde for proofreading my thesis. In addition, a thank to Lene T. Skovgaard for statistical advise and Carsten Pedersen for his technical feedback on the wholebody plethysmography. Furthermore I wish to thank the parties, which supported the studies financially: The Danish Pediatric Asthma Center; Næstved Hospital; Region Sjælland; Østdansk Sundhedsvidenskabeligt Forskningsforum; Den Sundhedsvidenskabelige Forskningsfond - Region 3; Storstrømmens forskningsråd; Lægekredsforeningen for Storstrøms Amt Forskningsfond; Dansk Selskab for Pædiatrisk Allergologi og Pulmonologi; MedImmune. Thanks to Jensen Bøfhus for sponsoring dinner to the participating families who travelled around the country with me. The COPSAC cohort is funded by several research funds which are acknowledged on the website: www.copsac.com. A special thanks to all the children and parents who participated in the studies. I would also like to thank my mother, father and sister for giving me the best foundation in life. Finally, I wish to thank my love and best friend Villads for never-ending encouragement, patience and immense support. Thank you for letting me know what is important in life. 4
Abbreviations ANOVA ASC BHR BTPS CI COPSAC ELISA F E NO FEV 0.5 FEV 1 kPa MZ OR P P amb P H2O PtcO 2 PCR PD PD 15 PD 20 PP P RSV RVRTC SD SD w sRaw sRawTOT V ANalysis Of VAriance [Automatischer Schleifen-Computer] Bronchial Hyper Responsiveness Body Temperature, barometric Pressure and Saturated with water vapour Confidence Interval COPenhagen Studies on Asthma in Childhood Enzyme-Linked ImmunoSorbent Assay Fractional Exhaled Nitric Oxide Forced Expiratory Volume at 0.5 seconds Forced Exipiratory Volume at first second kiloPascal MonoZygotic Odds Ratio Pressure Ambient Presurre Pressure of Water vapour at body temperature Transcutaneuous Oxygen Pressure Polymerase Chain Reaction Provocative Dose Provocative Dose of methacholine producing a 15 percent fall in lung function Provocative Dose of methacholine producing a 20 percent fall in lung function Observer Porntiva Poorisrisak Change in Pressure Respiratory Syncytial Virus Raised Volume Rapid Thoracic Compression Standard Deviation Within subject Standard Deviation Specific Airway Resistance Parameter line connecting the flow points at maximum change in plethysmographic volume (pressure) Volume Airflow Change in Airflow 5
Page 1: Lung function measurements in child
Page 4 and 5: Contents Acknowledgements .........
Page 8 and 9: Introduction Symptoms of chronic re
Page 10 and 11: pulmonary function test obtained by
Page 12 and 13: I. Accuracy of Wholebody Plethysmog
Page 14 and 15: Methods Designs Study I: Six center
Page 16 and 17: "Loops" on the screen showed the re
Page 18 and 19: We included age in the analysis of
Page 20 and 21: Normative data (study I) Mean sRaw
Page 22 and 23: Additional results sRaw measurement
Page 24 and 25: After correcting the factory settin
Page 26 and 27: Normative data In the second part o
Page 28 and 29: II. -III. Lung function measurement
Page 30 and 31: of a diagnosis of asthma: Frequent
Page 32 and 33: Figure 8: Familial predisposition t
Page 34 and 35: Total twins 12.349 twin pairs Born
Page 36 and 37: Methods Designs Study II: Hospital
Page 38 and 39: Children less than 7 years were tes
Page 40 and 41: Ethics The two studies were approve
Page 42 and 43: FEV 0.5 (ml) Table 4: Baseline char
Page 44 and 45: lung symptoms, 19% said it was the
Page 46 and 47: symptoms in response to verified RS
Page 48 and 49: epigenetic factors. Acute environme
Page 50 and 51: detection changes in lung function
Page 52 and 53: that small airways were not the dis
Page 54 and 55: onciolitis. There is an increasing
Page 56 and 57:
further studies are needed to inves
Page 58 and 59:
Summary The Ph.D. thesis is based o
Page 60 and 61:
Danish summary (Dansk resumé) Denn
Page 62 and 63:
References Reference List (1) Lum S
Page 64 and 65:
(25) Aurora P, Gustafsson P, Bush A
Page 66 and 67:
(50) Klug B, Bisgaard H. Repeatabil
Page 68 and 69:
(76) Meissner HC. Economic impact o
Page 70 and 71:
(101) Young S, Arnott J, O'Keeffe P
Page 72 and 73:
(125) Bisgaard H, Hermansen MN, Lol
Page 74 and 75:
(151) Walton RP, Johnston SL. Role
Page 76 and 77:
disease in otherwise healthy infant
Page 78 and 79:
changes in asthma control. Am J Res
Page 81:
Paper I
Page 84 and 85:
CHEST Original Research Accuracy of
Page 86 and 87:
Figure 1. Center agreement study: l
Page 88 and 89:
observer as well as a common observ
Page 90 and 91:
sRaw (kPa*s) Figure 1 Online: Cente
Page 93 and 94:
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 95 and 96:
54 55 56 57 INTRODUCTION Respirator
Page 97 and 98:
97 98 99 100 Lung function test Chi
Page 99 and 100:
141 142 143 144 Mean gestational ag
Page 101 and 102:
186 187 188 189 190 The discordant
Page 103 and 104:
232 233 234 235 236 237 viruses and
Page 105 and 106:
278 ACKNOWLEDGMENTS 279 280 281 282
Page 107 and 108:
335 336 (21) Bisgaard H, Nielsen KG
Page 109 and 110:
394 395 396 (42) Wu P, Dupont WD, G
Page 111 and 112:
455 456 457 (64) Bisgaard H, Herman
Page 113 and 114:
488 489 Table 1: Comparison of clin
Page 115:
Paper III
Page 118 and 119:
Abstract Background: Two-three perc
Page 120 and 121:
RA 08 TSM 133; Respiratory Care Cen
Page 122 and 123:
prospectively if baseline lung func
Page 124 and 125:
who do not develop RSV bronchioliti
Page 126 and 127:
Acknowledgements We thank all the c
Page 128 and 129:
(24) ATS/ERS statement: raised volu
Page 130 and 131:
(53) Stein RT, Sherrill D, Morgan W
Page 132 and 133:
Figure 1: Flow chart COPSAC cohort
show all

Lung function measurements in children - copsac

Create successful ePaper yourself

Delete template?

Save as template?