Lung function measurements in children - copsac
Lung function measurements in children - copsac
Lung function measurements in children - copsac
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elated to asthma or simply identifies <strong>in</strong>fants at risk for subsequent wheez<strong>in</strong>g from an<br />
atopic predisposition or pre-exist<strong>in</strong>g abnormal lung <strong>function</strong>.<br />
First aim was to determ<strong>in</strong>e the differential effect with<strong>in</strong> monozygotic tw<strong>in</strong> (MZ) pairs<br />
discordant for severe RSV bronchiolitis <strong>in</strong> <strong>in</strong>fancy on the subsequent development of<br />
asthma, pulmonary <strong>function</strong> and allergy. 37 MZ tw<strong>in</strong> pairs discordant for RSV<br />
hospitalization <strong>in</strong> <strong>in</strong>fancy were compared at the mean age of 7.6 years for lung <strong>function</strong><br />
and bronchial responsiveness. We found no differences with<strong>in</strong> MZ tw<strong>in</strong> pairs with<br />
respect to pulmonary <strong>function</strong>, fractional exhaled nitric oxide, asthma prevalence,<br />
asthma medication use, or sensitization.<br />
Secondary aim was to compare prospectively the basel<strong>in</strong>e lung <strong>function</strong> and bronchial<br />
responsiveness <strong>in</strong> <strong>in</strong>fants who later develop RSV bronchiolitis with <strong>in</strong>fants who do not<br />
develop such severe <strong>in</strong>fection. In a prospective birth cohort study of 411 <strong>in</strong>fants of<br />
asthmatic mothers 22 <strong>in</strong>fants developed RSV bronchiolitis. Infants with and without<br />
RSV bronchiolitis did not differ significantly <strong>in</strong> basel<strong>in</strong>e lung <strong>function</strong> or bronchial<br />
responsiveness.<br />
Conclusion: We found no effect of severe RSV bronchiolitis on the development of<br />
asthma and abnormal pulmonary <strong>function</strong>, nor did basel<strong>in</strong>e lung <strong>function</strong> seem to<br />
predict later development of RSV bronchiolitis. This ague aga<strong>in</strong>st a specific effect of the<br />
RSV bronchiolitis <strong>in</strong> the development of asthma and may suggest a genetic factor or an<br />
undisclosed environmental predispos<strong>in</strong>g to severe RSV bronchiolitis, maybe co<strong>in</strong>fection<br />
rather than mechanical difference as the dist<strong>in</strong>guish<strong>in</strong>g feature for the<br />
development of RSV bronchiolitis.<br />
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