Lung function measurements in children - copsac
Lung function measurements in children - copsac
Lung function measurements in children - copsac
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Table 3: Comparison of cl<strong>in</strong>ical endpo<strong>in</strong>ts at follow-up between monozygotic tw<strong>in</strong> pairs discordant<br />
for hospitalization for severe respiratory syncytial virus bronchiolitis<br />
Hospitalized vs. not-hospitalized<br />
P-value<br />
Asthma OR (95% CI) 1.21 (0.36-4.00) 1.00 a<br />
History of atopic dermatitis OR (95% CI) 1.14 (0.41-3.14) 1.00 a<br />
Use of <strong>in</strong>halation steroid ever OR (95% CI) 1.26 (0.49-3.22) 0.81 a<br />
Use of beta2-agonist ever OR (95% CI) 1.38 (0.55-3.46) 0.64 a<br />
logF E NO (n = 30) Pbb mean (SD) 2.05 (0.66) 2.17 (0.69) 0.16 b<br />
logBasel<strong>in</strong>e FEV 1 (n = 25) L mean (SD) 0.42 (0.26) 0.46 (0.23) 0.12 b<br />
logMethachol<strong>in</strong>e PD20 (n =24) mol mean (SD) 0.74 (1.83) 0.41 (1.71) 0.27 b<br />
logsRaw basel<strong>in</strong>e (n = 12) kPa*s mean (SD) 0.18 (0.26) 0.19 (0.30) 0.79 b<br />
sRaw after dry air<br />
hyperventilation (n = 5)<br />
% <strong>in</strong>crease<br />
(median)<br />
27% 18% 0.40 c<br />
Positive sk<strong>in</strong> prick test OR (95% CI) 0.36 (0.07-2.08) 0.43 a<br />
n = number of tw<strong>in</strong> pairs which completed the test<br />
a<br />
Fisher’s exact test<br />
b<br />
Paired t-test<br />
c<br />
Wilcoxon's test (paired)<br />
Neonatal lung <strong>function</strong> prior RSV <strong>in</strong>fection (study III)<br />
Twenty-two <strong>in</strong>fants developed RSV bronchiolitis before age 2 (16 boys); 17 of the 22<br />
<strong>children</strong> were under 1 year old when diagnosed with RSV bronchiolitis (mean age 5.7<br />
months). N<strong>in</strong>eteen of the 22 <strong>children</strong> were hospitalized with RSV bronchiolitis (mean<br />
duration of 4.7 days). <strong>Lung</strong> <strong>function</strong> had been completed more than 1 week prior to the<br />
bronchiolitis. Basel<strong>in</strong>e characteristics of the lung <strong>function</strong> <strong>measurements</strong> are shown <strong>in</strong><br />
table 4.<br />
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