Lung function measurements in children - copsac
Lung function measurements in children - copsac
Lung function measurements in children - copsac
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Ethics<br />
The two studies were approved by the local ethics committee (KA-20060022 and<br />
(KF)01-227/97) respectively) and by the Danish Data Protection Agency (J.nr. 2005-41-<br />
5163, J.nr. 2005-2311-0121and 2008-41-1754, respectively).<br />
The <strong>children</strong> were enrolled after written consent was obta<strong>in</strong>ed from the parents or<br />
guardians.<br />
Results<br />
Tw<strong>in</strong> study: <strong>Lung</strong> <strong>function</strong> after RSV <strong>in</strong>fection (study II)<br />
Mean gestational age of the tw<strong>in</strong> pairs was 35.5 weeks (median 36 weeks; <strong>in</strong>terquartile<br />
range 34-38 weeks). There was no significant difference between RSV hospitalized and<br />
non-hospitalized tw<strong>in</strong>s with respect to birth weight (mean 2369g; <strong>in</strong>terquartile range<br />
2034-2750g), neonatal treatment for lung complications (Cont<strong>in</strong>uous Positive Airway<br />
Pressure, surfactant or pneumothorax) and birth order (22/37 probands were first born).<br />
Forty-n<strong>in</strong>e % of the tw<strong>in</strong> pairs had parental atopic predispositions. The average age<br />
when hospitalized for severe RSV bronchiolitis was 10.6 months (<strong>in</strong>terquartile range:<br />
5.1-13.3); median age 8.4 months. Mean duration of hospitalization was 4.3 days.<br />
Accord<strong>in</strong>g to the <strong>in</strong>terviews (GINA guidel<strong>in</strong>es) the prevalence of asthma was 18% <strong>in</strong><br />
our tw<strong>in</strong> sample. The tw<strong>in</strong>s did not differ with respect to current asthma; use of <strong>in</strong>haled<br />
corticosteroid or beta 2 -agonist ever; atopic dermatitis ever; F E NO; basel<strong>in</strong>e lung<br />
<strong>function</strong>; bronchial responsiveness or sensitization (Table 3).<br />
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