Lung function measurements in children - copsac

More documents

Recommendations

Info

Contents Acknowledgements ........................................................................................................................... 4 Abbreviations .................................................................................................................................... 5 Introduction ....................................................................................................................................... 6 Lung function techniques in children........................................................................................... 6 I. Accuracy of Wholebody Plethysmography in preschool children ........................................... 10 Background ...................................................................................................................................... 10 Quality control of wholebody plethysmography ....................................................................... 10 Aims (study I) .................................................................................................................................. 11 Material ............................................................................................................................................ 11 Study I .......................................................................................................................................... 11 Methods ........................................................................................................................................... 12 Designs......................................................................................................................................... 12 Wholebody Plethysmography ..................................................................................................... 12 Statistical analyses ...................................................................................................................... 15 Ethics............................................................................................................................................ 16 Results .............................................................................................................................................. 16 Center agreement (study I) ......................................................................................................... 16 Normative data (study I) ............................................................................................................. 18 Discussion ........................................................................................................................................ 21 II. -III.Lung function measurements before and after RSV Bronchiolitis ................................... 26 Background ...................................................................................................................................... 26 Respiratory syncytial virus infection in infancy ........................................................................ 26 Asthma in childhood ................................................................................................................... 27 2
Causal direction between Respiratory syncytial virus bronchiolitis and asthma ................... 29 Aims (study II-III) ........................................................................................................................... 30 Material ............................................................................................................................................ 31 Study II ......................................................................................................................................... 31 Study III ....................................................................................................................................... 33 Methods ........................................................................................................................................... 34 Designs......................................................................................................................................... 34 Lung function measurements ...................................................................................................... 35 Statistical analyses ...................................................................................................................... 37 Ethics............................................................................................................................................ 38 Results .............................................................................................................................................. 38 Twin study: Lung function after RSV infection (study II) ......................................................... 38 Neonatal lung function prior RSV infection (study III) ............................................................ 39 Discussion ........................................................................................................................................ 41 Conclusion and future perspectives ............................................................................................... 53 Study I .......................................................................................................................................... 53 Study II-III ................................................................................................................................... 55 Summary .......................................................................................................................................... 56 Danish summary (Dansk resumé) .................................................................................................. 58 References........................................................................................................................................ 60 Appendix .......................................................................................................................................... 76 Papers I-III .................................................................................................................................. 77 3
Page 1: Lung function measurements in child
Page 6 and 7: Acknowledgements The thesis was wri
Page 8 and 9: Introduction Symptoms of chronic re
Page 10 and 11: pulmonary function test obtained by
Page 12 and 13: I. Accuracy of Wholebody Plethysmog
Page 14 and 15: Methods Designs Study I: Six center
Page 16 and 17: "Loops" on the screen showed the re
Page 18 and 19: We included age in the analysis of
Page 20 and 21: Normative data (study I) Mean sRaw
Page 22 and 23: Additional results sRaw measurement
Page 24 and 25: After correcting the factory settin
Page 26 and 27: Normative data In the second part o
Page 28 and 29: II. -III. Lung function measurement
Page 30 and 31: of a diagnosis of asthma: Frequent
Page 32 and 33: Figure 8: Familial predisposition t
Page 34 and 35: Total twins 12.349 twin pairs Born
Page 36 and 37: Methods Designs Study II: Hospital
Page 38 and 39: Children less than 7 years were tes
Page 40 and 41: Ethics The two studies were approve
Page 42 and 43: FEV 0.5 (ml) Table 4: Baseline char
Page 44 and 45: lung symptoms, 19% said it was the
Page 46 and 47: symptoms in response to verified RS
Page 48 and 49: epigenetic factors. Acute environme
Page 50 and 51: detection changes in lung function
Page 52 and 53: that small airways were not the dis
Page 54 and 55:
onciolitis. There is an increasing
Page 56 and 57:
further studies are needed to inves
Page 58 and 59:
Summary The Ph.D. thesis is based o
Page 60 and 61:
Danish summary (Dansk resumé) Denn
Page 62 and 63:
References Reference List (1) Lum S
Page 64 and 65:
(25) Aurora P, Gustafsson P, Bush A
Page 66 and 67:
(50) Klug B, Bisgaard H. Repeatabil
Page 68 and 69:
(76) Meissner HC. Economic impact o
Page 70 and 71:
(101) Young S, Arnott J, O'Keeffe P
Page 72 and 73:
(125) Bisgaard H, Hermansen MN, Lol
Page 74 and 75:
(151) Walton RP, Johnston SL. Role
Page 76 and 77:
disease in otherwise healthy infant
Page 78 and 79:
changes in asthma control. Am J Res
Page 81:
Paper I
Page 84 and 85:
CHEST Original Research Accuracy of
Page 86 and 87:
Figure 1. Center agreement study: l
Page 88 and 89:
observer as well as a common observ
Page 90 and 91:
sRaw (kPa*s) Figure 1 Online: Cente
Page 93 and 94:
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 95 and 96:
54 55 56 57 INTRODUCTION Respirator
Page 97 and 98:
97 98 99 100 Lung function test Chi
Page 99 and 100:
141 142 143 144 Mean gestational ag
Page 101 and 102:
186 187 188 189 190 The discordant
Page 103 and 104:
232 233 234 235 236 237 viruses and
Page 105 and 106:
278 ACKNOWLEDGMENTS 279 280 281 282
Page 107 and 108:
335 336 (21) Bisgaard H, Nielsen KG
Page 109 and 110:
394 395 396 (42) Wu P, Dupont WD, G
Page 111 and 112:
455 456 457 (64) Bisgaard H, Herman
Page 113 and 114:
488 489 Table 1: Comparison of clin
Page 115:
Paper III
Page 118 and 119:
Abstract Background: Two-three perc
Page 120 and 121:
RA 08 TSM 133; Respiratory Care Cen
Page 122 and 123:
prospectively if baseline lung func
Page 124 and 125:
who do not develop RSV bronchioliti
Page 126 and 127:
Acknowledgements We thank all the c
Page 128 and 129:
(24) ATS/ERS statement: raised volu
Page 130 and 131:
(53) Stein RT, Sherrill D, Morgan W
Page 132 and 133:
Figure 1: Flow chart COPSAC cohort
show all

Lung function measurements in children - copsac

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?