Lung function measurements in children - copsac
Lung function measurements in children - copsac
Lung function measurements in children - copsac
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Study III<br />
“Copenhagen Prospective Study on Asthma <strong>in</strong> Childhood” (COPSAC) is a prospective<br />
cl<strong>in</strong>ical study of a birth-cohort, which <strong>in</strong>cluded <strong>measurements</strong> of basel<strong>in</strong>e lung <strong>function</strong><br />
and bronchial responsiveness to methachol<strong>in</strong>e at 1 month by <strong>in</strong>fant spirometry (123).<br />
The close cl<strong>in</strong>ical follow-up allowed prospective identification of <strong>in</strong>fants who<br />
developed RSV bronchiolitis.<br />
411 <strong>in</strong>fants born at term (203 boys) of mothers with physician-diagnosed asthma were<br />
enrolled at the age of 1 month <strong>in</strong> the birth cohort study COPSAC (124-126).<br />
Twenty-two <strong>in</strong>fants developed RSV bronchiolitis before age 2 years; mean age 8<br />
months (<strong>in</strong>terquartile range 3-12 months). The control group consisted of 366 <strong>children</strong>,<br />
exclud<strong>in</strong>g the 22 with RSV bronchiolitis and 23 with acute severe wheezy exacerbations<br />
from the ma<strong>in</strong> cohort of 411 (Figure 10).<br />
COPSAC cohort<br />
n=411<br />
Acute wheezy exacerbations<br />
n=45<br />
Control group n=366<br />
No acute severe wheezy<br />
exacerbations or bronchiolitis<br />
diagnosed dur<strong>in</strong>g 2 years of followup<br />
Figure 10: Flow chart<br />
RSV bronchiolitis<br />
n=22<br />
33
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