Lung function measurements in children - copsac
Lung function measurements in children - copsac
Lung function measurements in children - copsac
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Figure 8: Familial predisposition to asthma relates to w<strong>in</strong>ter viral <strong>in</strong>fection and asthma,<br />
w<strong>in</strong>ter viral <strong>in</strong>fection is <strong>in</strong> the causal pathway of development of asthma (118).<br />
Thus, many studies <strong>in</strong>dicate an association between RSV hospitalization <strong>in</strong> <strong>in</strong>fancy and<br />
wheez<strong>in</strong>g and atopic disease, but it is unclear whether severe RSV bronchiolitis causes<br />
wheez<strong>in</strong>g, or genetic predisposition or environmental risk factors <strong>in</strong>crease the<br />
propensity to such exaggerated response to RSV.<br />
Aims (study II-III)<br />
Study II<br />
To compare the long-term outcome of asthma, allergy and pulmonary<br />
<strong>function</strong> <strong>in</strong> monozygotic (MZ) tw<strong>in</strong> pairs discordant for hospitalization with<br />
verified RSV bronchiolitis <strong>in</strong> <strong>in</strong>fancy as a surrogate marker of the RSV<br />
disease severity. Any differential long-term effect from RSV disease severity<br />
<strong>in</strong> these genetically identical tw<strong>in</strong>s would suggest a causal role of RSV.<br />
Study III<br />
To compare the preexist<strong>in</strong>g basel<strong>in</strong>e lung <strong>function</strong> and bronchial<br />
responsiveness <strong>in</strong> <strong>in</strong>fants who later develop RSV bronchiolitis with those<br />
who do not develop RSV bronchiolitis.<br />
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