Lung function measurements in children - copsac

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Normative data (study I) Mean sRaw (SD) was 1.21 kPa * s (0.33) independent of height, weight, age and gender (Table 2); within-subject SD (variability) was 0.07 calculated by using mixed model with repeated measurements. There was no significant effect of center. Furthermore, there was no effect of the child’s history of atopy, parental atopy or smoking (p-values > 0.05 for all estimates). Table 2: Normative study: Clinical characteristics of the children from the 5 centers Estimate Center no. 1 2 3 4 5 Total [CI] Number of children Mean sRaw (SD) Mean age (SD) Gender/boys (%) Weight/kg (SD) Height/cm (SD) 21 28 29 16 11 105 1.30 (0.32) 5.39 (1.16) 11 (52) 22.0 (4.29) 115.2 (8.95) 1.09 (0.24) 5.24 (1.04) 15 (54) 20.0 (4.84) 110.2 (9.90) 1.26 (0.31) 5.07 (1.18) 16 (55) 20.4 (4.32) 112.3 (9.79) 1.28 (0.46) 4.53 (1.19) 6 (38) 18.9 (4.24) 106.2 (8.27) 1.10 (0.23) 5.39 (1.03) 4 (36) 19.4 (2.88) 111.2 (8.28) 1.21 (0.33) 5.13 (1.15) 52 (49.5) 20.3 (4.39) 111.3 (9.61) Rhinitis (%) 4 (19) 0 (0) 4 (14) 1 (6.3) 1 (9.0) 10 (9.5) Dermatitis (%) Parental atopy (%) 2 (9.5) 12 (57) 10 (36) 13 (46) 5 (17) 21 (75) 4 (25) 11 (69) 1 (9.0) 5 (45) 22 (20.9) 62 (59.6) Smoking (%) 4 (19) 8 (29) 4 (14) 3 (19) 4 (36) 23 (22) 0.98 [0.93-1.03] 1.05 [0.98-1.13] 1.01 [0.99-1.03] 0.99 [0.99-1.01] 0.91 [0.79-1.04] 1.05 [0.96-1.15] 0.99 [0.92-1.07] 1.02 [0.94-1.11] p- value 0.47 0.16 0.26 0.52 0.16 0.29 0.85 0.64 We pooled the previous report on normative data by Klug and Bisgaard (121 children) (12) and the current normative data (105 children); mean sRaw (SD) 1.27 (0.25); 95% CI [0.78-1.76] (Figure 5). 18
Figure 5: Normative data from the multicenter study (5 centers) and the previous study (Klug & Bisgaard, 1997) The sRaw values fitted a normal distribution (Figure 6). Figure 6: Normal distribution of sRaw values with 2.5 and 97.5 percentiles. 19
Page 1: Lung function measurements in child
Page 4 and 5: Contents Acknowledgements .........
Page 6 and 7: Acknowledgements The thesis was wri
Page 8 and 9: Introduction Symptoms of chronic re
Page 10 and 11: pulmonary function test obtained by
Page 12 and 13: I. Accuracy of Wholebody Plethysmog
Page 14 and 15: Methods Designs Study I: Six center
Page 16 and 17: "Loops" on the screen showed the re
Page 18 and 19: We included age in the analysis of
Page 22 and 23: Additional results sRaw measurement
Page 24 and 25: After correcting the factory settin
Page 26 and 27: Normative data In the second part o
Page 28 and 29: II. -III. Lung function measurement
Page 30 and 31: of a diagnosis of asthma: Frequent
Page 32 and 33: Figure 8: Familial predisposition t
Page 34 and 35: Total twins 12.349 twin pairs Born
Page 36 and 37: Methods Designs Study II: Hospital
Page 38 and 39: Children less than 7 years were tes
Page 40 and 41: Ethics The two studies were approve
Page 42 and 43: FEV 0.5 (ml) Table 4: Baseline char
Page 44 and 45: lung symptoms, 19% said it was the
Page 46 and 47: symptoms in response to verified RS
Page 48 and 49: epigenetic factors. Acute environme
Page 50 and 51: detection changes in lung function
Page 52 and 53: that small airways were not the dis
Page 54 and 55: onciolitis. There is an increasing
Page 56 and 57: further studies are needed to inves
Page 58 and 59: Summary The Ph.D. thesis is based o
Page 60 and 61: Danish summary (Dansk resumé) Denn
Page 62 and 63: References Reference List (1) Lum S
Page 64 and 65: (25) Aurora P, Gustafsson P, Bush A
Page 66 and 67: (50) Klug B, Bisgaard H. Repeatabil
Page 68 and 69: (76) Meissner HC. Economic impact o
Page 70 and 71:
(101) Young S, Arnott J, O'Keeffe P
Page 72 and 73:
(125) Bisgaard H, Hermansen MN, Lol
Page 74 and 75:
(151) Walton RP, Johnston SL. Role
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disease in otherwise healthy infant
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changes in asthma control. Am J Res
Page 81:
Paper I
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CHEST Original Research Accuracy of
Page 86 and 87:
Figure 1. Center agreement study: l
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observer as well as a common observ
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sRaw (kPa*s) Figure 1 Online: Cente
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 95 and 96:
54 55 56 57 INTRODUCTION Respirator
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97 98 99 100 Lung function test Chi
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141 142 143 144 Mean gestational ag
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186 187 188 189 190 The discordant
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232 233 234 235 236 237 viruses and
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278 ACKNOWLEDGMENTS 279 280 281 282
Page 107 and 108:
335 336 (21) Bisgaard H, Nielsen KG
Page 109 and 110:
394 395 396 (42) Wu P, Dupont WD, G
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455 456 457 (64) Bisgaard H, Herman
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488 489 Table 1: Comparison of clin
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Paper III
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Abstract Background: Two-three perc
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RA 08 TSM 133; Respiratory Care Cen
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prospectively if baseline lung func
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who do not develop RSV bronchioliti
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Acknowledgements We thank all the c
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(24) ATS/ERS statement: raised volu
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(53) Stein RT, Sherrill D, Morgan W
Page 132 and 133:
Figure 1: Flow chart COPSAC cohort
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