Lung function measurements in children - copsac
Lung function measurements in children - copsac
Lung function measurements in children - copsac
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Normative data (study I)<br />
Mean sRaw (SD) was 1.21 kPa * s (0.33) <strong>in</strong>dependent of height, weight, age and gender<br />
(Table 2); with<strong>in</strong>-subject SD (variability) was 0.07 calculated by us<strong>in</strong>g mixed model<br />
with repeated <strong>measurements</strong>. There was no significant effect of center. Furthermore,<br />
there was no effect of the child’s history of atopy, parental atopy or smok<strong>in</strong>g (p-values<br />
> 0.05 for all estimates).<br />
Table 2: Normative study: Cl<strong>in</strong>ical characteristics of the <strong>children</strong> from the 5 centers<br />
Estimate<br />
Center no. 1 2 3 4 5 Total<br />
[CI]<br />
Number of<br />
<strong>children</strong><br />
Mean sRaw<br />
(SD)<br />
Mean age<br />
(SD)<br />
Gender/boys<br />
(%)<br />
Weight/kg<br />
(SD)<br />
Height/cm<br />
(SD)<br />
21 28 29 16 11 105<br />
1.30<br />
(0.32)<br />
5.39<br />
(1.16)<br />
11<br />
(52)<br />
22.0<br />
(4.29)<br />
115.2<br />
(8.95)<br />
1.09<br />
(0.24)<br />
5.24<br />
(1.04)<br />
15<br />
(54)<br />
20.0<br />
(4.84)<br />
110.2<br />
(9.90)<br />
1.26<br />
(0.31)<br />
5.07<br />
(1.18)<br />
16<br />
(55)<br />
20.4<br />
(4.32)<br />
112.3<br />
(9.79)<br />
1.28<br />
(0.46)<br />
4.53<br />
(1.19)<br />
6<br />
(38)<br />
18.9<br />
(4.24)<br />
106.2<br />
(8.27)<br />
1.10<br />
(0.23)<br />
5.39<br />
(1.03)<br />
4<br />
(36)<br />
19.4<br />
(2.88)<br />
111.2<br />
(8.28)<br />
1.21<br />
(0.33)<br />
5.13<br />
(1.15)<br />
52<br />
(49.5)<br />
20.3<br />
(4.39)<br />
111.3<br />
(9.61)<br />
Rh<strong>in</strong>itis (%) 4 (19) 0 (0) 4 (14) 1 (6.3) 1 (9.0) 10 (9.5)<br />
Dermatitis<br />
(%)<br />
Parental<br />
atopy (%)<br />
2<br />
(9.5)<br />
12<br />
(57)<br />
10<br />
(36)<br />
13<br />
(46)<br />
5<br />
(17)<br />
21<br />
(75)<br />
4<br />
(25)<br />
11<br />
(69)<br />
1<br />
(9.0)<br />
5<br />
(45)<br />
22<br />
(20.9)<br />
62<br />
(59.6)<br />
Smok<strong>in</strong>g (%) 4 (19) 8 (29) 4 (14) 3 (19) 4 (36) 23 (22)<br />
0.98<br />
[0.93-1.03]<br />
1.05<br />
[0.98-1.13]<br />
1.01<br />
[0.99-1.03]<br />
0.99<br />
[0.99-1.01]<br />
0.91<br />
[0.79-1.04]<br />
1.05<br />
[0.96-1.15]<br />
0.99<br />
[0.92-1.07]<br />
1.02<br />
[0.94-1.11]<br />
p-<br />
value<br />
0.47<br />
0.16<br />
0.26<br />
0.52<br />
0.16<br />
0.29<br />
0.85<br />
0.64<br />
We pooled the previous report on normative data by Klug and Bisgaard (121 <strong>children</strong>)<br />
(12) and the current normative data (105 <strong>children</strong>); mean sRaw (SD) 1.27 (0.25); 95%<br />
CI [0.78-1.76] (Figure 5).<br />
18
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