Lung function measurements in children - copsac
Lung function measurements in children - copsac
Lung function measurements in children - copsac
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We <strong>in</strong>cluded age <strong>in</strong> the analysis of center agreement because of the small number of<br />
<strong>children</strong>, and preschool <strong>children</strong> could theoretically have a higher variation of sRaw<br />
values throughout the many visits. Our data were powered to detect a difference of<br />
0.078 <strong>in</strong> expected log(sRaw) between two pre-specified centers. If centers were not prespecified<br />
our data were powered to detect a difference of 0.117 us<strong>in</strong>g Bonferroni<br />
correction. For the normative data (<strong>in</strong>cl. SD) we used mixed model with repeated<br />
<strong>measurements</strong> us<strong>in</strong>g log-transformed sRaw values adjusted for center number. A<br />
comparison between data from center no. 3 with previous reported normative values<br />
was done us<strong>in</strong>g a two sample t-test for means with logtransformed sRaw values. The<br />
figures were made by us<strong>in</strong>g Analyse-it for Excel.<br />
Ethics<br />
Study I was approved by the Local Ethics Committee as a quality assurance project and<br />
approved by the Danish Data Protection Agency (J.nr. 2005-2-11).<br />
Results<br />
Center agreement (study I)<br />
All 7 <strong>children</strong> (3 boys) completed <strong>measurements</strong> at each of the 6 centers. <strong>Lung</strong> <strong>function</strong><br />
<strong>measurements</strong> differed significantly between centers (Figure 4).<br />
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