Lung function measurements in children - copsac

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We included age in the analysis of center agreement because of the small number of children, and preschool children could theoretically have a higher variation of sRaw values throughout the many visits. Our data were powered to detect a difference of 0.078 in expected log(sRaw) between two pre-specified centers. If centers were not prespecified our data were powered to detect a difference of 0.117 using Bonferroni correction. For the normative data (incl. SD) we used mixed model with repeated measurements using log-transformed sRaw values adjusted for center number. A comparison between data from center no. 3 with previous reported normative values was done using a two sample t-test for means with logtransformed sRaw values. The figures were made by using Analyse-it for Excel. Ethics Study I was approved by the Local Ethics Committee as a quality assurance project and approved by the Danish Data Protection Agency (J.nr. 2005-2-11). Results Center agreement (study I) All 7 children (3 boys) completed measurements at each of the 6 centers. Lung function measurements differed significantly between centers (Figure 4). 16
Figure 4: Center agreement study. Least squares mean for sRaw on 6 centers with 95% CI (software versions are indicated in parenthesis). sRaw at center no. 1 and 2 were significantly lower compared to the other 4 centers and center no. 6 had significantly higher sRaw values than all the other centers. Mean sRaw (SD) for all 6 centers was 0.88 kPa*s (0.23). The within-subject SD was 0.01 and between-center SD for each child was 0.02. Observer and age of the child did not significantly affect the measurements (p>0.5). There were no significant difference between the sRaw results obtained by PP and the local operator (table 1). Table 1: Normative study: sRaw results obtained by PP and the local operator Child no Center no 1 2 3 4 5 6 7 PP Local operator PP Local operator PP Local operator PP Local operator PP Local operator PP Local operator PP Local operator 1 0.75 0.75 1.05 0.97 0.98 1.07 1.31 1.05 0.92 0.93 0.73 0.79 0.75 0.77 2 0.69 0.68 0.67 0.67 0.86 0.95 0.87 0.83 0.86 0.79 1.09 1.01 0.65 0.59 3 0.51 0.44 0.61 0.61 0.51 0.65 0.46 0.61 0.74 0.67 1.05 1.02 0.43 0.65 4 0.99 0.74 0.79 0.76 1.13 1.11 0.93 0.90 0.88 0.96 1.29 1.33 0.81 0.77 5 1.54 1.41 1.09 0.97 1.02 1.02 0.99 1.13 0.95 0.87 1.20 1.08 0.82 0.71 6 0.82 0.87 0.89 0.88 0.86 1.01 1.11 1.09 0.74 0.91 1.14 1.29 0.76 0.77 17
Page 1: Lung function measurements in child
Page 4 and 5: Contents Acknowledgements .........
Page 6 and 7: Acknowledgements The thesis was wri
Page 8 and 9: Introduction Symptoms of chronic re
Page 10 and 11: pulmonary function test obtained by
Page 12 and 13: I. Accuracy of Wholebody Plethysmog
Page 14 and 15: Methods Designs Study I: Six center
Page 16 and 17: "Loops" on the screen showed the re
Page 20 and 21: Normative data (study I) Mean sRaw
Page 22 and 23: Additional results sRaw measurement
Page 24 and 25: After correcting the factory settin
Page 26 and 27: Normative data In the second part o
Page 28 and 29: II. -III. Lung function measurement
Page 30 and 31: of a diagnosis of asthma: Frequent
Page 32 and 33: Figure 8: Familial predisposition t
Page 34 and 35: Total twins 12.349 twin pairs Born
Page 36 and 37: Methods Designs Study II: Hospital
Page 38 and 39: Children less than 7 years were tes
Page 40 and 41: Ethics The two studies were approve
Page 42 and 43: FEV 0.5 (ml) Table 4: Baseline char
Page 44 and 45: lung symptoms, 19% said it was the
Page 46 and 47: symptoms in response to verified RS
Page 48 and 49: epigenetic factors. Acute environme
Page 50 and 51: detection changes in lung function
Page 52 and 53: that small airways were not the dis
Page 54 and 55: onciolitis. There is an increasing
Page 56 and 57: further studies are needed to inves
Page 58 and 59: Summary The Ph.D. thesis is based o
Page 60 and 61: Danish summary (Dansk resumé) Denn
Page 62 and 63: References Reference List (1) Lum S
Page 64 and 65: (25) Aurora P, Gustafsson P, Bush A
Page 66 and 67: (50) Klug B, Bisgaard H. Repeatabil
Page 68 and 69:
(76) Meissner HC. Economic impact o
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(101) Young S, Arnott J, O'Keeffe P
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(125) Bisgaard H, Hermansen MN, Lol
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(151) Walton RP, Johnston SL. Role
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disease in otherwise healthy infant
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changes in asthma control. Am J Res
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Paper I
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CHEST Original Research Accuracy of
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Figure 1. Center agreement study: l
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observer as well as a common observ
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sRaw (kPa*s) Figure 1 Online: Cente
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
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54 55 56 57 INTRODUCTION Respirator
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97 98 99 100 Lung function test Chi
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141 142 143 144 Mean gestational ag
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186 187 188 189 190 The discordant
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232 233 234 235 236 237 viruses and
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278 ACKNOWLEDGMENTS 279 280 281 282
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335 336 (21) Bisgaard H, Nielsen KG
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394 395 396 (42) Wu P, Dupont WD, G
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455 456 457 (64) Bisgaard H, Herman
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488 489 Table 1: Comparison of clin
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Paper III
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Abstract Background: Two-three perc
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RA 08 TSM 133; Respiratory Care Cen
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prospectively if baseline lung func
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who do not develop RSV bronchioliti
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Acknowledgements We thank all the c
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(24) ATS/ERS statement: raised volu
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(53) Stein RT, Sherrill D, Morgan W
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Figure 1: Flow chart COPSAC cohort
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